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Zongertinib Side Effects

The most commonly reported side effects of zongertinib include diarrhoea, malignant neoplasm progression, and hepatic cytolysis, based on 23 FDA adverse event reports from 2017 to 2025.

Zongertinib side effects

Percentages show how often each reaction appears relative to total reports for zongertinib.

1
Diarrhoea17.4%4
2
Malignant Neoplasm Progression17.4%4
3
Hepatic Cytolysis13.0%3
4
Epistaxis13.0%3
5
Decreased Appetite13.0%3
6
Hepatitis8.7%2
7
Paraesthesia Oral8.7%2
8
Dry Mouth8.7%2
9
Weight Decreased8.7%2
10
Rash8.7%2
11
Prescribed Overdose8.7%2
12
Pain8.7%2
13
Pyrexia8.7%2
14
Pericardial Effusion8.7%2
15
Infantile Apnoea4.3%1

These are voluntary reports and do not establish that zongertinib caused these reactions.

Report severity

60.9%Serious14 reports
34.8%Hospitalizations8 reports
0.0%Fatal0 reports

Seriousness is determined by the reporter, not by OpenClaim.

Zongertinib drug interactions

Other drugs that appear in adverse event reports alongside zongertinib. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Apixaban13.0%3
2
Palivizumab4.3%1

Taken alongside

1
Nitroglycerin13.0%3
2
Bisoprolol-fumarate13.0%3
3
Lorazepam13.0%3
4
Ursodiol13.0%3
5
Vilanterol-trifenatate13.0%3
6
Umeclidinium-bromide13.0%3
7
Atorvastatin-calcium13.0%3
8
Albuterol8.7%2
9
Calcium-chloride4.3%1
10
Dextrose4.3%1
11
Magnesium-chloride4.3%1
12
Sodium-acetate4.3%1
13
Sodium-chloride4.3%1
14
Aspirin4.3%1
15
Amlodipine4.3%1

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports zongertinib side effects

69.6% of zongertinib adverse event reports involve female patients and 30.4% involve male patients. The largest age group is elderly at 56%. These figures reflect who reports side effects, not underlying risk.

Sex

Female69.6%
Male30.4%
Unknown0.0%

Age group

< 26.3%
2–110.0%
12–170.0%
18–6437.5%
65+56.3%

What is zongertinib used for

Conditions and purposes for which patients were taking zongertinib when the adverse event was reported.

Bronchial CarcinomaHer2 Mutant Non-small Cell Lung CancerLung Neoplasm MalignantMetastases To Central Nervous SystemNon-small Cell Lung CancerNon-small Cell Lung Cancer MetastaticNon-small Cell Lung Cancer Stage IvProduct Used For Unknown IndicationProduct Used For Unknown Indication

Zongertinib brand names and reporting trend

Zongertinib is sold under the brand name Hernexeos.

Brand names

Hernexeos8

Quarterly reports (20172025)

20172025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking zongertinib with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.