OpenClaim

Zolmitriptan Side Effects

The most commonly reported side effects of zolmitriptan include headache, migraine, and off label use, based on 7,389 FDA adverse event reports from 2004 to 2025. 8.4% of reports found the drug to be ineffective.

Zolmitriptan side effects

Percentages show how often each reaction appears relative to total reports for zolmitriptan.

1
Headache9.7%716
2
Migraine9.4%694
3
Drug Ineffective8.4%623
4
Off Label Use6.3%469
5
Nausea6.2%460
6
Fatigue5.7%422
7
Migraine5.1%378
8
Pain4.6%338
9
Drug Intolerance4.1%305
10
Dizziness3.6%268
11
Vomiting3.6%263
12
Malaise3.1%232
13
Dyspnoea3.0%223
14
Headache3.0%219
15
Insomnia2.9%217

These are voluntary reports and do not establish that zolmitriptan caused these reactions.

Report severity

63.2%Serious4,668 reports
24.0%Hospitalizations1,775 reports
2.5%Fatal183 reports

Seriousness is determined by the reporter, not by OpenClaim.

Zolmitriptan drug interactions

Other drugs that appear in adverse event reports alongside zolmitriptan. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Topiramate6.7%496
2
Sumatriptan6.0%446
3
Acetaminophen4.9%363
4
Sodium-oxybate4.6%340
5
Rizatriptan-benzoate3.9%290
6
Erenumab-aooe3.8%282
7
Venlafaxine3.7%277
8
Propranolol-hydrochloride3.7%275
9
Sertraline-hydrochloride3.1%232
10
Duloxetine-hydrochloride3.0%222
11
Albuterol3.0%219
12
Amoxicillin2.9%217
13
Dexamethasone2.9%214
14
Esomeprazole2.9%213
15
Eszopiclone2.8%209

Taken alongside

1
Acetaminophen15.1%1,116
2
Ergocalciferol9.0%667
3
Albuterol9.0%662
4
Topiramate8.9%661
5
Levothyroxine-sodium8.9%658
6
Fluticasone7.9%582
7
Omeprazole7.3%543
8
Ibuprofen7.2%532
9
Naproxen6.6%490
10
Amitriptyline-hydrochloride6.6%489
11
Gabapentin6.6%488
12
Duloxetine-hydrochloride6.0%440
13
Sumatriptan5.9%439
14
Ondansetron5.8%426
15
Pantoprazole-sodium5.5%403

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports zolmitriptan side effects

78.5% of zolmitriptan adverse event reports involve female patients and 13.5% involve male patients. The largest age group is adult at 84%. These figures reflect who reports side effects, not underlying risk.

Sex

Female78.5%
Male13.5%
Unknown8.0%

Age group

< 21.0%
2–110.3%
12–172.2%
18–6484.4%
65+12.1%

What is zolmitriptan used for

Conditions and purposes for which patients were taking zolmitriptan when the adverse event was reported.

AmnesiaAnalgesic TherapyAnorectal DisorderAnxietyArnold-chiari MalformationAccidental Exposure To ProductAdverse Drug ReactionAnalgesic TherapyCancer PainCluster HeadacheCompleted SuicideConjunctival HyperaemiaCranial Nerve DisorderCrohn's DiseaseCluster Headache

Showing 15 of 75 indications

Zolmitriptan brand names and reporting trend

Zolmitriptan is sold under the brand name Zomig.

Brand names

Zomig2,846

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking zolmitriptan with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.