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Zoledronic Side Effects

The most commonly reported side effects of zoledronic include osteonecrosis of jaw, fatigue, and osteonecrosis, based on 86,381 FDA adverse event reports from 2004 to 2025.

Zoledronic side effects

Percentages show how often each reaction appears relative to total reports for zoledronic.

1
Osteonecrosis Of Jaw7.3%6,282
2
Fatigue6.7%5,749
3
Osteonecrosis6.5%5,616
4
Diarrhoea5.3%4,559
5
Nausea4.9%4,205
6
Pain4.8%4,185
7
Death4.8%4,119
8
Arthralgia4.1%3,554
9
Pyrexia4.0%3,425
10
Asthenia3.6%3,109
11
Vomiting3.3%2,816
12
Dyspnoea3.1%2,681
13
Headache3.1%2,652
14
Off Label Use3.1%2,648
15
Back Pain3.0%2,587

These are voluntary reports and do not establish that zoledronic caused these reactions.

Report severity

85.6%Serious73,936 reports
29.2%Hospitalizations25,189 reports
14.9%Fatal12,892 reports

Seriousness is determined by the reporter, not by OpenClaim.

Zoledronic drug interactions

Other drugs that appear in adverse event reports alongside zoledronic. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Lenalidomide15.7%13,559
2
Dexamethasone5.2%4,535
3
Letrozole3.7%3,156
4
Pomalidomide3.4%2,953
5
Palbociclib3.2%2,781
6
Bortezomib3.0%2,599
7
Pamidronate-disodium2.9%2,475
8
Docetaxel2.5%2,158
9
Trastuzumab2.4%2,101
10
Ribociclib2.2%1,932
11
Denosumab2.1%1,807
12
Paclitaxel2.0%1,703
13
Capecitabine1.9%1,657
14
Bevacizumab1.7%1,501
15
Fulvestrant1.7%1,465

Taken alongside

1
Dexamethasone14.3%12,311
2
Aspirin12.4%10,669
3
Acetaminophen11.5%9,952
4
Ergocalciferol10.4%9,006
5
Acyclovir8.6%7,415
6
Calcium8.5%7,356
7
Omeprazole7.7%6,651
8
Levothyroxine-sodium6.3%5,399
9
Oxycodone6.1%5,262
10
Ondansetron5.3%4,606
11
Gabapentin5.0%4,349
12
Furosemide5.0%4,293
13
Bortezomib4.8%4,188
14
Pantoprazole-sodium4.7%4,089
15
Amlodipine4.7%4,042

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports zoledronic side effects

60.5% of zoledronic adverse event reports involve female patients and 33.5% involve male patients. The largest age group is elderly at 56%. These figures reflect who reports side effects, not underlying risk.

Sex

Female60.5%
Male33.5%
Unknown5.9%

Age group

< 2<0.1%
2–110.7%
12–170.5%
18–6443.0%
65+55.7%

What is zoledronic used for

Conditions and purposes for which patients were taking zoledronic when the adverse event was reported.

Abdominal NeoplasmAcquired Gene MutationAcral Lentiginous MelanomaAcute Lymphocytic LeukaemiaAcute Myeloid LeukaemiaAdenocarcinomaAdenocarcinoma GastricAdenocarcinoma Of ColonAdenocarcinoma Of The CervixAdenoma BenignAdenosquamous Cell Lung Cancer Stage IvAdjuvant TherapyAdult T-cell Lymphoma/leukaemiaAdverse EventAlbright^s Disease

Showing 15 of 1,034 indications

Zoledronic brand names and reporting trend

Zoledronic is sold under the brand name Zoledronic.

Brand names

Zoledronic30,623

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking zoledronic with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.