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Zolbetuximab Side Effects

The most commonly reported side effects of zolbetuximab include nausea, vomiting, and decreased appetite, based on 899 FDA adverse event reports from 2019 to 2025.

Zolbetuximab side effects

Percentages show how often each reaction appears relative to total reports for zolbetuximab.

1
Nausea40.4%363
2
Vomiting18.4%165
3
Decreased Appetite14.1%127
4
Malignant Neoplasm Progression8.6%77
5
Hypoalbuminaemia8.2%74
6
Ascites8.1%73
7
Diarrhoea6.2%56
8
Blood Albumin Decreased5.6%50
9
Malaise4.9%44
10
Neutrophil Count Decreased4.7%42
11
Oedema Peripheral4.6%41
12
Abdominal Pain4.2%38
13
Myelosuppression4.1%37
14
Pyrexia4.0%36
15
Dehydration3.9%35

These are voluntary reports and do not establish that zolbetuximab caused these reactions.

Report severity

84.9%Serious763 reports
36.4%Hospitalizations327 reports
13.8%Fatal124 reports

Seriousness is determined by the reporter, not by OpenClaim.

Zolbetuximab drug interactions

Other drugs that appear in adverse event reports alongside zolbetuximab. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Oxaliplatin30.6%275
2
Capecitabine16.1%145
3
Fluorouracil14.3%129
4
Levoleucovorin8.1%73
5
Paclitaxel2.6%23
6
Gemcitabine2.0%18
7
Nivolumab1.6%14
8
Olanzapine1.4%13
9
Leucovorin-calcium1.3%12
10
Ramucirumab0.6%5
11
Dexchlorpheniramine-maleate0.6%5
12
Clonidine0.4%4
13
Dexamethasone0.4%4
14
Denosumab0.4%4
15
Calcium0.3%3

Taken alongside

1
Oxaliplatin21.0%189
2
Fluorouracil12.1%109
3
Levoleucovorin12.1%109
4
Capecitabine11.8%106
5
Dexamethasone11.2%101
6
Palonosetron-hydrochloride9.9%89
7
Olanzapine7.7%69
8
Netupitant6.7%60
9
Metoclopramide-hydrochloride4.9%44
10
Dexchlorpheniramine-maleate4.2%38
11
Aprepitant4.1%37
12
Ondansetron3.4%31
13
Lorazepam3.1%28
14
Chlorpheniramine3.1%28
15
Nivolumab3.0%27

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports zolbetuximab side effects

32.3% of zolbetuximab adverse event reports involve female patients and 61.5% involve male patients. The largest age group is elderly at 67%. These figures reflect who reports side effects, not underlying risk.

Sex

Female32.3%
Male61.5%
Unknown6.2%

Age group

< 20.0%
2–110.0%
12–170.5%
18–6432.6%
65+66.9%

What is zolbetuximab used for

Conditions and purposes for which patients were taking zolbetuximab when the adverse event was reported.

Adenocarcinoma GastricAdenocarcinoma MetastaticAdenocarcinoma PancreasAdenocarcinoma GastricAdenocarcinoma Gastric Stage IvAdenocarcinoma PancreasBone CancerChemotherapyColon CancerGastric CancerGastrointestinal Cancer MetastaticGastrooesophageal CancerGastric CancerGastric Cancer RecurrentGastric Cancer Stage Iii

Showing 15 of 46 indications

Zolbetuximab brand names and reporting trend

Zolbetuximab is sold under the brand name Vyloy.

Brand names

Vyloy246

Quarterly reports (20192025)

20192020202220242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking zolbetuximab with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.