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Ziprasidone Side Effects

The most commonly reported side effects of ziprasidone include diabetes mellitus, type 2 diabetes mellitus, and weight increased, based on 20,406 FDA adverse event reports from 2004 to 2025. 7.3% of reports found the drug to be ineffective.

#1 Reported: Diabetes MellitusAll side effects ↓Top Co-Medication: Quetiapine-fumarateDrug interactions ↓84% of Reports Are AdultDemographics ↓

Ziprasidone side effects

Percentages show how often each reaction appears relative to total reports for ziprasidone.

1
Drug Ineffective7.3%1,492
2
Diabetes Mellitus4.6%947
3
Type 2 Diabetes Mellitus3.9%794
4
Weight Increased3.8%771
5
Suicide Attempt3.4%702
6
Weight Increased3.1%642
7
Dyskinesia3.1%635
8
Sedation3.0%605
9
Anxiety2.7%561
10
Condition Aggravated2.7%548
11
Tardive Dyskinesia2.6%530
12
Off Label Use2.6%526
13
Dystonia2.6%526
14
Sexual Dysfunction2.5%506
15
Insomnia2.5%501

These are voluntary reports and do not establish that ziprasidone caused these reactions.

Report severity

70.6%Serious14,408 reports
25.2%Hospitalizations5,142 reports
7.9%Fatal1,614 reports

Seriousness is determined by the reporter, not by OpenClaim.

Ziprasidone drug interactions

Other drugs that appear in adverse event reports alongside ziprasidone. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Quetiapine-fumarate16.3%3,324
2
Olanzapine10.0%2,049
3
Aripiprazole8.2%1,671
4
Risperidone8.0%1,627
5
Clozapine5.5%1,118
6
Lamotrigine3.7%753
7
Paliperidone3.4%689
8
Lithium3.3%666
9
Asenapine3.2%659
10
Haloperidol3.2%655
11
Lurasidone-hydrochloride3.2%651
12
Clonazepam2.2%440
13
Sertraline-hydrochloride2.1%438
14
Fluoxetine-hydrochloride2.0%409
15
Gabapentin2.0%407

Taken alongside

1
Clonazepam9.8%1,993
2
Risperidone7.7%1,565
3
Lamotrigine7.4%1,502
4
Trazodone-hydrochloride6.9%1,417
5
Acetaminophen6.7%1,375
6
Lorazepam6.7%1,370
7
Bupropion6.4%1,308
8
Aripiprazole6.1%1,254
9
Divalproex-sodium6.0%1,229
10
Levothyroxine-sodium5.9%1,211
11
Gabapentin5.9%1,195
12
Olanzapine5.5%1,125
13
Sertraline-hydrochloride5.3%1,078
14
Alprazolam4.9%1,010
15
Metformin4.9%997

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports ziprasidone side effects

54.9% of ziprasidone adverse event reports involve female patients and 34.0% involve male patients. The largest age group is adult at 84%. These figures reflect who reports side effects, not underlying risk.

Sex

Female54.9%
Male34.0%
Unknown11.2%

Age group

< 20.4%
2–112.5%
12–175.2%
18–6483.9%
65+8.0%

What is ziprasidone used for

Conditions and purposes for which patients were taking ziprasidone when the adverse event was reported.

Abdominal DiscomfortAbnormal BehaviourAccidental ExposureAccidental Exposure To ProductAcute ManiaAcute PsychosisAdjustment DisorderAdjustment Disorder With Depressed MoodAdjustment Disorder With Mixed Anxiety And Depressed MoodAdjuvant TherapyAffect LabilityAffective DisorderAggressionAgitated DepressionAgitation

Showing 15 of 415 indications

Ziprasidone brand names and reporting trend

Ziprasidone is sold under the brand name Geodon.

Brand names

Geodon65

Quarterly reports (2004–2025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking ziprasidone with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.

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