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Zinc Sulfate Side Effects

The most commonly reported side effects of zinc sulfate include diarrhoea, fatigue, and off label use, based on 2,976 FDA adverse event reports from 2004 to 2025. 2.6% of reports found the drug to be ineffective.

Zinc Sulfate side effects

Percentages show how often each reaction appears relative to total reports for zinc sulfate.

1
Diarrhoea6.4%190
2
Fatigue5.6%166
3
Off Label Use5.2%155
4
Death4.8%143
5
Nausea4.6%138
6
Pain4.1%122
7
Dyspnoea4.0%118
8
Vomiting3.8%113
9
Pyrexia3.7%110
10
Acute Kidney Injury3.3%99
11
Alanine Aminotransferase Increased3.1%92
12
Malaise2.9%85
13
Pneumonia2.8%84
14
Headache2.8%82
15
Fall2.7%80

These are voluntary reports and do not establish that zinc sulfate caused these reactions.

Report severity

76.4%Serious2,273 reports
44.0%Hospitalizations1,310 reports
14.8%Fatal439 reports

Seriousness is determined by the reporter, not by OpenClaim.

Zinc Sulfate drug interactions

Other drugs that appear in adverse event reports alongside zinc sulfate. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Remdesivir10.5%312
2
Lenalidomide6.1%183
3
Adalimumab3.2%94
4
Venetoclax2.9%87
5
Sodium-chloride2.8%84
6
Dexamethasone2.5%75
7
Cyclophosphamide2.5%73
8
Ascorbic-acid2.3%69
9
Infliximab1.9%57
10
Hydrocortisone1.9%56
11
Potassium-chloride1.8%55
12
Ergocalciferol1.8%54
13
Folic-acid1.8%54
14
Dupilumab1.8%54
15
Morphine-sulfate1.7%52

Taken alongside

1
Ascorbic-acid35.3%1,051
2
Ergocalciferol31.1%926
3
Acetaminophen29.2%870
4
Aspirin21.9%651
5
Furosemide18.5%552
6
Pantoprazole-sodium18.4%547
7
Ondansetron16.4%488
8
Albuterol16.1%478
9
Folic-acid14.8%441
10
Levothyroxine-sodium14.2%423
11
Dexamethasone14.1%419
12
Omeprazole14.0%416
13
Metoprolol13.3%396
14
Insulin12.7%379
15
Atorvastatin-calcium12.6%375

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports zinc sulfate side effects

47.8% of zinc sulfate adverse event reports involve female patients and 45.0% involve male patients. The largest age group is adult at 52%. These figures reflect who reports side effects, not underlying risk.

Sex

Female47.8%
Male45.0%
Unknown7.3%

Age group

< 21.1%
2–112.5%
12–172.3%
18–6451.9%
65+42.2%

What is zinc sulfate used for

Conditions and purposes for which patients were taking zinc sulfate when the adverse event was reported.

Acute Respiratory FailureAdverse EventAlopeciaAnaemiaAcrodermatitis EnteropathicaAlveolar RhabdomyosarcomaAnorectal DiscomfortBlood Zinc AbnormalBlood Zinc DecreasedBlood Zinc DecreasedComplications Of Transplanted LiverConfusional StateCongenital AnomalyCoronavirus InfectionCovid-19

Showing 15 of 110 indications

Zinc Sulfate brand names and reporting trend

Zinc Sulfate is sold under the brand name Zinc Sulfate.

Brand names

Zinc Sulfate3,105

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking zinc sulfate with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.