OpenClaim

Zilucoplan Side Effects

The most commonly reported side effects of zilucoplan include myasthenia gravis, product dose omission issue, and injection site pain, based on 582 FDA adverse event reports from 2023 to 2025. 21.0% of reports found the drug to be ineffective.

Zilucoplan side effects

Percentages show how often each reaction appears relative to total reports for zilucoplan.

1
Myasthenia Gravis39.3%229
2
Drug Ineffective21.0%122
3
Product Dose Omission Issue12.5%73
4
Injection Site Pain11.5%67
5
Fatigue8.8%51
6
Diarrhoea6.9%40
7
Hospitalisation5.7%33
8
Myasthenia Gravis Crisis5.3%31
9
Weight Increased4.6%27
10
Weight Decreased4.3%25
11
Pneumonia4.3%25
12
Dyspnoea4.1%24
13
Urinary Tract Infection4.1%24
14
Therapy Interrupted4.0%23
15
Nausea4.0%23

These are voluntary reports and do not establish that zilucoplan caused these reactions.

Report severity

82.3%Serious479 reports
38.8%Hospitalizations226 reports
4.3%Fatal25 reports

Seriousness is determined by the reporter, not by OpenClaim.

Zilucoplan drug interactions

Other drugs that appear in adverse event reports alongside zilucoplan. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Rozanolixizumab-noli4.6%27
2
Efgartigimod3.3%19
3
Prednisolone3.3%19
4
Pyridostigmine-bromide3.1%18
5
Rituximab2.9%17
6
Prednisone2.6%15
7
Methotrexate2.6%15
8
Ravulizumab-cwvz2.1%12
9
Mycophenolate1.7%10
10
Azathioprine1.5%9
11
Eculizumab0.9%5
12
Sertraline-hydrochloride0.9%5
13
Tirzepatide0.7%4
14
Amifampridine0.7%4
15
Semaglutide0.3%2

Taken alongside

1
Pyridostigmine-bromide38.7%225
2
Prednisone32.0%186
3
Ergocalciferol20.4%119
4
Omeprazole11.9%69
5
Mycophenolate10.5%61
6
Acetaminophen9.8%57
7
Aspirin9.8%57
8
Cyanocobalamin9.3%54
9
Atorvastatin-calcium8.9%52
10
Calcium8.9%52
11
Levothyroxine-sodium8.2%48
12
Pantoprazole-sodium7.9%46
13
Gabapentin7.6%44
14
Prednisolone7.4%43
15
Metformin6.5%38

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports zilucoplan side effects

35.7% of zilucoplan adverse event reports involve female patients and 29.6% involve male patients. The largest age group is adult at 56%. These figures reflect who reports side effects, not underlying risk.

Sex

Female35.7%
Male29.6%
Unknown34.7%

Age group

< 20.0%
2–110.0%
12–170.0%
18–6455.7%
65+44.3%

What is zilucoplan used for

Conditions and purposes for which patients were taking zilucoplan when the adverse event was reported.

Amyotrophic Lateral SclerosisAnxietyMuscular WeaknessMyasthenia GravisOff Label UseProduct Used For Unknown Indication

Zilucoplan brand names and reporting trend

Zilucoplan is sold under the brand name Zilbrysq.

Brand names

Zilbrysq617

Quarterly reports (20232025)

202320242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking zilucoplan with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.