OpenClaim

Ziconotide Side Effects

The most commonly reported side effects of ziconotide include device issue, off label use, and pain, based on 2,657 FDA adverse event reports from 2004 to 2025. 9.4% of reports found the drug to be ineffective.

Ziconotide side effects

Percentages show how often each reaction appears relative to total reports for ziconotide.

1
Device Issue12.0%320
2
Off Label Use11.4%303
3
Pain11.4%302
4
Drug Ineffective9.4%250
5
Nausea6.4%171
6
Confusional State6.3%168
7
Hallucination5.8%153
8
Hallucination, Auditory4.5%119
9
Dizziness4.4%118
10
Headache3.9%104
11
Drug Withdrawal Syndrome3.6%96
12
Vomiting3.3%89
13
Fall3.2%85
14
Pain3.0%80
15
Somnolence3.0%80

These are voluntary reports and do not establish that ziconotide caused these reactions.

Report severity

52.2%Serious1,387 reports
26.1%Hospitalizations694 reports
4.9%Fatal131 reports

Seriousness is determined by the reporter, not by OpenClaim.

Ziconotide drug interactions

Other drugs that appear in adverse event reports alongside ziconotide. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Hydromorphone-hydrochloride14.9%395
2
Baclofen13.5%359
3
Bupivacaine11.6%308
4
Fentanyl7.7%204
5
Apomorphine-hydrochloride7.6%201
6
Clonidine6.4%170
7
Morphine-sulfate5.5%146
8
Sufentanil-citrate1.4%36
9
Pregabalin1.3%35
10
Oxycodone1.0%27
11
Gabapentin0.9%23
12
Methadone-hydrochloride0.8%22
13
Acetaminophen0.8%20
14
Duloxetine-hydrochloride0.8%20
15
Fluoxetine-hydrochloride0.7%19

Taken alongside

1
Hydromorphone-hydrochloride6.4%171
2
Oxycodone5.6%149
3
Gabapentin5.6%149
4
Acetaminophen4.9%129
5
Duloxetine-hydrochloride4.0%106
6
Baclofen3.9%104
7
Fentanyl3.8%101
8
Apomorphine-hydrochloride3.5%93
9
Pregabalin3.0%80
10
Bupivacaine2.9%77
11
Clonidine2.7%72
12
Hydrocodone2.4%64
13
Furosemide2.4%64
14
Levothyroxine-sodium2.3%61
15
Clonazepam2.2%59

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports ziconotide side effects

42.4% of ziconotide adverse event reports involve female patients and 37.0% involve male patients. The largest age group is adult at 73%. These figures reflect who reports side effects, not underlying risk.

Sex

Female42.4%
Male37.0%
Unknown20.6%

Age group

< 20.1%
2–110.1%
12–170.1%
18–6473.0%
65+26.6%

What is ziconotide used for

Conditions and purposes for which patients were taking ziconotide when the adverse event was reported.

Abdominal PainAccidental ExposureAnalgesic TherapyAngina PectorisArachnoiditisArthralgiaArthritisArthropathyAstrocytomaAutonomic NeuropathyAnalgesic TherapyAnkylosing SpondylitisArachnoiditisArthralgiaBack Disorder

Showing 15 of 178 indications

Ziconotide brand names and reporting trend

Ziconotide is sold under the brand name Prialt.

Brand names

Prialt276

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking ziconotide with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.