OpenClaim

Zavegepant Side Effects

The most commonly reported side effects of zavegepant include dysgeusia, nasal discomfort, and nausea, based on 750 FDA adverse event reports from 2018 to 2025. 16.7% of reports found the drug to be ineffective.

Zavegepant side effects

Percentages show how often each reaction appears relative to total reports for zavegepant.

1
Dysgeusia29.5%221
2
Drug Ineffective16.7%125
3
Nasal Discomfort10.5%79
4
Nausea9.3%70
5
Throat Irritation8.4%63
6
Vomiting7.6%57
7
Therapeutic Product Effect Incomplete5.6%42
8
Migraine4.8%36
9
Headache4.5%34
10
Off Label Use4.5%34
11
Taste Disorder4.5%34
12
Burning Sensation3.6%27
13
Oropharyngeal Pain2.5%19
14
Upper-airway Cough Syndrome2.4%18
15
Dizziness2.1%16

These are voluntary reports and do not establish that zavegepant caused these reactions.

Report severity

8.3%Serious62 reports
2.0%Hospitalizations15 reports
0.0%Fatal0 reports

Seriousness is determined by the reporter, not by OpenClaim.

Zavegepant drug interactions

Other drugs that appear in adverse event reports alongside zavegepant. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Rimegepant3.1%23
2
Eptinezumab-jjmr3.1%23
3
Aspirin1.5%11
4
Onabotulinumtoxina1.5%11
5
Diclofenac1.5%11
6
Topiramate1.3%10
7
Etanercept1.3%10
8
Atorvastatin-calcium1.3%10
9
Propafenone-hydrochloride1.3%10
10
Levetiracetam1.3%10
11
Sulfasalazine1.3%10
12
Methotrexate1.3%10
13
Folic-acid1.3%10
14
Atenolol1.3%10
15
Metformin1.3%10

Taken alongside

1
Rimegepant4.3%32
2
Acetaminophen3.7%28
3
Ubrogepant3.6%27
4
Onabotulinumtoxina3.1%23
5
Ondansetron2.1%16
6
Ergocalciferol2.0%15
7
Gabapentin1.9%14
8
Caffeine1.9%14
9
Albuterol1.7%13
10
Aspirin1.7%13
11
Levothyroxine-sodium1.6%12
12
Atogepant1.5%11
13
Topiramate1.5%11
14
Ibuprofen1.2%9
15
Sumatriptan1.2%9

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports zavegepant side effects

70.4% of zavegepant adverse event reports involve female patients and 8.4% involve male patients. The largest age group is adult at 95%. These figures reflect who reports side effects, not underlying risk.

Sex

Female70.4%
Male8.4%
Unknown21.2%

Age group

< 20.0%
2–110.0%
12–170.0%
18–6494.7%
65+5.3%

What is zavegepant used for

Conditions and purposes for which patients were taking zavegepant when the adverse event was reported.

Back PainCystitisCluster HeadacheEye DisorderHeadacheHemiplegic MigraineInfectionMigraineMigraine ProphylaxisMigraine With AuraMigraine Without AuraProduct Used For Unknown IndicationPainProduct Used For Unknown Indication

Zavegepant brand names and reporting trend

Zavegepant is sold under the brand name Zavzpret.

Brand names

Zavzpret77

Quarterly reports (20182025)

201820242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking zavegepant with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.