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Zanubrutinib Side Effects

The most commonly reported side effects of zanubrutinib include off label use, disease progression, and white blood cell count decreased, based on 3,541 FDA adverse event reports from 2019 to 2025. 3.5% of reports found the drug to be ineffective.

Zanubrutinib side effects

Percentages show how often each reaction appears relative to total reports for zanubrutinib.

1
Off Label Use14.2%504
2
Disease Progression7.3%259
3
White Blood Cell Count Decreased6.2%218
4
Anaemia5.8%204
5
Platelet Count Decreased5.7%202
6
Myelosuppression5.7%201
7
Contusion5.6%199
8
Fatigue5.1%179
9
Rash4.9%175
10
Death4.6%163
11
Pneumonia4.5%159
12
Diarrhoea3.9%138
13
Asthenia3.9%137
14
Neutrophil Count Decreased3.8%134
15
Drug Ineffective3.5%125

These are voluntary reports and do not establish that zanubrutinib caused these reactions.

Report severity

75.1%Serious2,659 reports
26.3%Hospitalizations931 reports
11.5%Fatal407 reports

Seriousness is determined by the reporter, not by OpenClaim.

Zanubrutinib drug interactions

Other drugs that appear in adverse event reports alongside zanubrutinib. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Rituximab15.8%559
2
Cyclophosphamide8.9%315
3
Venetoclax8.3%295
4
Obinutuzumab6.3%222
5
Vincristine-sulfate5.9%209
6
Doxorubicin-hydrochloride5.8%205
7
Ibrutinib5.8%204
8
Bendamustine-hydrochloride4.7%166
9
Lenalidomide4.7%165
10
Polatuzumab-vedotin-piiq4.2%148
11
Prednisone4.1%144
12
Fludarabine-phosphate3.2%113
13
Cytarabine2.5%88
14
Prednisolone2.2%78
15
Dexamethasone2.0%72

Taken alongside

1
Acyclovir6.2%219
2
Allopurinol4.5%160
3
Acetaminophen4.5%158
4
Sulfamethoxazole4.4%156
5
Dexamethasone4.1%146
6
Prednisone4.0%140
7
Omeprazole3.7%130
8
Pantoprazole-sodium3.3%117
9
Ergocalciferol3.2%114
10
Furosemide3.2%112
11
Aspirin2.9%104
12
Cyclophosphamide2.9%101
13
Metoprolol2.7%97
14
Trimethoprim2.6%92
15
Atorvastatin-calcium2.6%92

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports zanubrutinib side effects

11.9% of zanubrutinib adverse event reports involve female patients and 17.9% involve male patients. The largest age group is elderly at 71%. These figures reflect who reports side effects, not underlying risk.

Sex

Female11.9%
Male17.9%
Unknown70.2%

Age group

< 20.0%
2–110.0%
12–17<0.1%
18–6429.4%
65+70.5%

What is zanubrutinib used for

Conditions and purposes for which patients were taking zanubrutinib when the adverse event was reported.

Adult T-cell Lymphoma/leukaemiaAcute Lymphocytic LeukaemiaAcute Myeloid LeukaemiaAmyloidosisAnogenital WartsAnti-myelin-associated Glycoprotein Associated PolyneuropathyB SymptomsB-cell LymphomaB-cell Small Lymphocytic LymphomaB-cell LymphomaB-cell Lymphoma RefractoryB-cell Small Lymphocytic LymphomaB-cell Small Lymphocytic Lymphoma Stage IvB-cell Type Acute LeukaemiaBing-neel Syndrome

Showing 15 of 136 indications

Zanubrutinib brand names and reporting trend

Zanubrutinib is sold under the brand name Brukinsa.

Brand names

Brukinsa1,032

Quarterly reports (20192025)

20192020202220242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking zanubrutinib with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.