OpenClaim

Zalcitabine Side Effects

The most commonly reported side effects of zalcitabine include virologic failure, viral mutation identified, and pathogen resistance, based on 268 FDA adverse event reports from 2004 to 2025. 5.6% of reports found the drug to be ineffective.

#1 Reported: Virologic FailureAll side effects ↓Top Co-Medication: LamivudineDrug interactions ↓87% of Reports Are AdultDemographics ↓

Zalcitabine side effects

Percentages show how often each reaction appears relative to total reports for zalcitabine.

1
Virologic Failure10.4%28
2
Viral Mutation Identified10.1%27
3
Pathogen Resistance9.0%24
4
Treatment Failure8.2%22
5
Drug Exposure During Pregnancy6.3%17
6
Mitochondrial Myopathy6.3%17
7
Drug Resistance6.0%16
8
Pyrexia5.6%15
9
Drug Resistance5.6%15
10
Drug Ineffective5.6%15
11
Diarrhoea5.2%14
12
Dyslipidaemia5.2%14
13
Hypertension4.9%13
14
Nausea4.5%12
15
Toxicity To Various Agents4.5%12

These are voluntary reports and do not establish that zalcitabine caused these reactions.

Report severity

95.1%Serious255 reports
28.7%Hospitalizations77 reports
16.8%Fatal45 reports

Seriousness is determined by the reporter, not by OpenClaim.

Zalcitabine drug interactions

Other drugs that appear in adverse event reports alongside zalcitabine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Lamivudine59.3%159
2
Zidovudine57.1%153
3
Stavudine54.9%147
4
Ritonavir45.1%121
5
Didanosine43.3%116
6
Tenofovir41.0%110
7
Saquinavir38.4%103
8
Abacavir35.1%94
9
Nelfinavir-mesylate31.3%84
10
Indinavir-sulfate29.5%79
11
Efavirenz29.1%78
12
Lopinavir23.9%64
13
Nevirapine21.3%57
14
Emtricitabine18.3%49
15
Raltegravir-potassium16.8%45

Taken alongside

1
Zidovudine20.5%55
2
Lamivudine17.5%47
3
Ritonavir15.7%42
4
Didanosine13.4%36
5
Abacavir11.6%31
6
Nevirapine10.1%27
7
Nelfinavir-mesylate10.1%27
8
Lopinavir9.3%25
9
Efavirenz8.6%23
10
Saquinavir8.2%22
11
Stavudine7.8%21
12
Tenofovir7.8%21
13
Amprenavir7.5%20
14
Indinavir-sulfate7.1%19
15
Sulfamethoxazole6.0%16

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports zalcitabine side effects

19.4% of zalcitabine adverse event reports involve female patients and 65.7% involve male patients. The largest age group is adult at 87%. These figures reflect who reports side effects, not underlying risk.

Sex

Female19.4%
Male65.7%
Unknown14.9%

Age group

< 22.1%
2–115.8%
12–172.6%
18–6487.3%
65+2.1%

What is zalcitabine used for

Conditions and purposes for which patients were taking zalcitabine when the adverse event was reported.

Acquired Immunodeficiency SyndromeAcute Hiv InfectionAntiretroviral TherapyAntiviral TreatmentAcquired Immunodeficiency SyndromeAntiretroviral TherapyCd4 Lymphocytes DecreasedDrug Exposure During PregnancyDrug Use For Unknown IndicationHiv InfectionHiv Infection Cdc Category C3Hiv Infection Cdc Group IHiv Test PositiveHiv InfectionProduct Used For Unknown Indication

Showing 15 of 18 indications

Zalcitabine brand names and reporting trend

Zalcitabine is sold under the brand name Hivid.

Brand names

Hivid211

Quarterly reports (2004–2025)

2005201020202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking zalcitabine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.

Check my medications