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Warfarin Side Effects

The most commonly reported side effects of warfarin include dyspnoea, international normalised ratio increased, and fatigue, based on 217,292 FDA adverse event reports from 2004 to 2025. 2.8% of reports found the drug to be ineffective.

Warfarin side effects

Percentages show how often each reaction appears relative to total reports for warfarin.

1
Dyspnoea5.3%11,429
2
International Normalised Ratio Increased4.3%9,337
3
Fatigue3.7%8,148
4
Diarrhoea3.6%7,927
5
Nausea3.4%7,391
6
International Normalised Ratio Increased3.3%7,221
7
Death3.2%6,959
8
Headache3.1%6,662
9
Fall3.0%6,413
10
Drug Ineffective2.8%6,123
11
Dizziness2.8%6,113
12
Drug Interaction2.8%6,068
13
Pneumonia2.6%5,586
14
Off Label Use2.5%5,459
15
Asthenia2.5%5,430

These are voluntary reports and do not establish that warfarin caused these reactions.

Report severity

77.4%Serious168,246 reports
46.7%Hospitalizations101,390 reports
12.6%Fatal27,486 reports

Seriousness is determined by the reporter, not by OpenClaim.

Warfarin drug interactions

Other drugs that appear in adverse event reports alongside warfarin. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Treprostinil5.4%11,787
2
Ambrisentan4.3%9,289
3
Lenalidomide4.1%8,879
4
Bosentan3.4%7,357
5
Aspirin2.9%6,252
6
Furosemide1.9%4,117
7
Macitentan1.7%3,679
8
Adalimumab1.6%3,453
9
Epoprostenol-sodium1.6%3,394
10
Enoxaparin-sodium1.5%3,208
11
Rivaroxaban1.5%3,174
12
Amiodarone-hydrochloride1.3%2,826
13
Digoxin1.3%2,773
14
Heparin1.2%2,538
15
Omeprazole1.1%2,489

Taken alongside

1
Furosemide18.0%39,181
2
Metoprolol10.9%23,630
3
Acetaminophen10.6%23,005
4
Aspirin10.6%22,935
5
Atorvastatin-calcium9.2%19,932
6
Levothyroxine-sodium8.8%19,030
7
Omeprazole7.7%16,666
8
Digoxin7.2%15,549
9
Lisinopril6.8%14,812
10
Amlodipine6.7%14,650
11
Ergocalciferol6.7%14,559
12
Simvastatin6.4%13,904
13
Albuterol5.8%12,677
14
Spironolactone5.6%12,132
15
Prednisone5.5%12,052

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports warfarin side effects

48.8% of warfarin adverse event reports involve female patients and 43.5% involve male patients. The largest age group is elderly at 63%. These figures reflect who reports side effects, not underlying risk.

Sex

Female48.8%
Male43.5%
Unknown7.7%

Age group

< 20.2%
2–110.4%
12–170.5%
18–6435.9%
65+63.0%

What is warfarin used for

Conditions and purposes for which patients were taking warfarin when the adverse event was reported.

Abdominal DiscomfortAbdominal InfectionAbdominal OperationAbdominal PainAbdominal Wall HaemorrhageAbdominoplastyAbnormal Clotting FactorAbnormal FaecesAccidental ExposureAccidental Exposure To ProductAccidental OverdoseAcquired DysfibrinogenaemiaAcquired HaemophiliaAcquired Protein S DeficiencyActivated Protein C Resistance

Showing 15 of 1,521 indications

Warfarin brand names and reporting trend

Warfarin is sold under brand names including Athrombin-k, Panwarfin.

Brand names

Athrombin-k96,643
Panwarfin51,854

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking warfarin with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.