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Vutrisiran Side Effects

The most commonly reported side effects of vutrisiran include death, hospitalisation, and intentional dose omission, based on 1,760 FDA adverse event reports from 2022 to 2025.

#1 Reported: DeathAll side effects ↓Top Co-Medication: TafamidisDrug interactions ↓89% of Reports Are ElderlyDemographics ↓

Vutrisiran side effects

Percentages show how often each reaction appears relative to total reports for vutrisiran.

1
Death17.8%313
2
Hospitalisation10.9%191
3
Intentional Dose Omission6.1%108
4
Fall4.4%78
5
Fatigue4.1%73
6
Therapy Interrupted4.0%70
7
Product Dose Omission Issue3.8%67
8
Dyspnoea3.1%55
9
Gait Disturbance3.0%52
10
Pain In Extremity2.9%51
11
Arthralgia2.6%45
12
Cardiac Failure2.6%45
13
Asthenia2.4%42
14
Dizziness2.4%42
15
Pain2.3%40

These are voluntary reports and do not establish that vutrisiran caused these reactions.

Report severity

82.6%Serious1,453 reports
39.1%Hospitalizations688 reports
22.9%Fatal403 reports

Seriousness is determined by the reporter, not by OpenClaim.

Vutrisiran drug interactions

Other drugs that appear in adverse event reports alongside vutrisiran. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Tafamidis2.3%41
2
Inotersen-sodium0.7%12
3
Patisiran-sodium0.6%11
4
Apixaban0.3%6
5
Acoramidis-hydrochloride0.3%6
6
Empagliflozin0.2%4
7
Vitamin-a0.2%3
8
Gabapentin0.2%3
9
Quetiapine-fumarate0.2%3
10
Tamsulosin-hydrochloride0.2%3
11
Sacubitril0.1%2
12
Valsartan0.1%2
13
Aspirin0.1%2
14
Atenolol0.1%2
15
Bumetanide0.1%2

Taken alongside

1
Tafamidis8.0%140
2
Vitamin-a4.1%73
3
Apixaban3.5%62
4
Furosemide3.3%58
5
Empagliflozin3.0%53
6
Spironolactone2.4%42
7
Ergocalciferol2.0%35
8
Atorvastatin-calcium1.9%34
9
Levothyroxine-sodium1.9%33
10
Aspirin1.9%33
11
Pregabalin1.8%32
12
Pantoprazole-sodium1.7%30
13
Torsemide1.5%27
14
Metformin1.5%26
15
Rosuvastatin1.5%26

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports vutrisiran side effects

1.3% of vutrisiran adverse event reports involve female patients and 1.7% involve male patients. The largest age group is elderly at 89%. These figures reflect who reports side effects, not underlying risk.

Sex

Female1.3%
Male1.7%
Unknown97.0%

Age group

< 20.0%
2–110.0%
12–170.0%
18–6411.1%
65+88.9%

What is vutrisiran used for

Conditions and purposes for which patients were taking vutrisiran when the adverse event was reported.

Acquired Attr AmyloidosisAdenomatous Polyposis ColiAmyloidosisAmyloidosis SenileCardiac AmyloidosisCardiac DisorderCardiomyopathyCardiovascular Event ProphylaxisDyskinesiaFamilial AmyloidosisHereditary Attr Amyloid CardiomyopathyHereditary Motor And Sensory NeuropathyHereditary Neuropathic AmyloidosisLiver TransplantNeuropathy Peripheral

Showing 15 of 18 indications

Vutrisiran brand names and reporting trend

Vutrisiran is sold under the brand name Amvuttra.

Brand names

Amvuttra15

Quarterly reports (2022–2025)

202220242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking vutrisiran with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.

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