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Voxilaprevir Side Effects

The most commonly reported side effects of voxilaprevir include fatigue, headache, and treatment failure, based on 1,101 FDA adverse event reports from 2017 to 2025. 10.0% of reports found the drug to be ineffective.

Voxilaprevir side effects

Percentages show how often each reaction appears relative to total reports for voxilaprevir.

1
Fatigue18.4%203
2
Headache12.6%139
3
Treatment Failure11.4%125
4
Drug Ineffective10.0%110
5
Nausea9.9%109
6
Hepatitis C8.4%93
7
Diarrhoea8.1%89
8
Vomiting3.3%36
9
Insomnia2.9%32
10
Hepatocellular Carcinoma2.3%25
11
Abdominal Discomfort2.1%23
12
Pruritus2.0%22
13
Decreased Appetite1.9%21
14
Asthenia1.9%21
15
Product Dose Omission1.8%20

These are voluntary reports and do not establish that voxilaprevir caused these reactions.

Report severity

38.2%Serious421 reports
7.2%Hospitalizations79 reports
3.2%Fatal35 reports

Seriousness is determined by the reporter, not by OpenClaim.

Voxilaprevir drug interactions

Other drugs that appear in adverse event reports alongside voxilaprevir. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Sofosbuvir96.5%1,062
2
Velpatasvir96.1%1,058
3
Ribavirin8.4%92
4
Ledipasvir2.5%28
5
Daclatasvir-dihydrochloride2.2%24
6
Grazoprevir1.1%12
7
Pibrentasvir1.0%11
8
Tenofovir0.9%10
9
Glecaprevir0.9%10
10
Elbasvir0.7%8
11
Simeprevir-sodium0.6%7
12
Emtricitabine0.5%5
13
Metformin0.5%5
14
Tacrolimus0.4%4
15
Boceprevir0.4%4

Taken alongside

1
Lisinopril3.5%39
2
Omeprazole3.5%39
3
Sofosbuvir3.5%39
4
Velpatasvir3.3%36
5
Amlodipine2.8%31
6
Albuterol2.4%26
7
Ribavirin2.3%25
8
Aspirin2.3%25
9
Metformin2.1%23
10
Gabapentin1.9%21
11
Ergocalciferol1.6%18
12
Spironolactone1.5%17
13
Methadone-hydrochloride1.5%17
14
Oxycodone1.4%15
15
Furosemide1.4%15

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports voxilaprevir side effects

28.2% of voxilaprevir adverse event reports involve female patients and 68.2% involve male patients. The largest age group is adult at 76%. These figures reflect who reports side effects, not underlying risk.

Sex

Female28.2%
Male68.2%
Unknown3.5%

Age group

< 20.0%
2–110.0%
12–170.0%
18–6475.6%
65+24.4%

What is voxilaprevir used for

Conditions and purposes for which patients were taking voxilaprevir when the adverse event was reported.

Alanine Aminotransferase IncreasedAcute Hepatitis CChronic HepatitisChronic Hepatitis CChronic HepatitisChronic Hepatitis BChronic Hepatitis CHepatic CancerHepatic CirrhosisHepatic FibrosisHepatitisHepatitis BHepatitis CHepatitis C Virus TestHepatitis C Virus Test Positive

Showing 15 of 26 indications

Voxilaprevir brand names and reporting trend

Voxilaprevir is sold under the brand name Vosevi.

Brand names

Vosevi31

Quarterly reports (20172025)

20182020202220242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking voxilaprevir with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.