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Voxelotor Side Effects

The most commonly reported side effects of voxelotor include sickle cell anaemia with crisis, product dose omission issue, and diarrhoea, based on 22,285 FDA adverse event reports from 2010 to 2025.

Voxelotor side effects

Percentages show how often each reaction appears relative to total reports for voxelotor.

1
Sickle Cell Anaemia With Crisis50.3%11,215
2
Product Dose Omission Issue23.2%5,171
3
Diarrhoea14.3%3,187
4
Off Label Use10.8%2,414
5
Nausea9.0%2,016
6
Headache7.6%1,691
7
Abdominal Pain Upper5.3%1,171
8
Pain4.9%1,083
9
Therapy Cessation4.7%1,041
10
Fatigue4.5%1,007
11
Abdominal Discomfort4.3%969
12
Therapy Interrupted4.0%900
13
Vomiting3.7%833
14
Haemoglobin Decreased3.4%750
15
Abdominal Pain2.8%627

These are voluntary reports and do not establish that voxelotor caused these reactions.

Report severity

43.1%Serious9,605 reports
35.2%Hospitalizations7,849 reports
1.9%Fatal415 reports

Seriousness is determined by the reporter, not by OpenClaim.

Voxelotor drug interactions

Other drugs that appear in adverse event reports alongside voxelotor. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
L-glutamine0.7%157
2
Hydroxyurea0.6%123
3
Deferiprone0.3%72
4
Deferasirox0.3%66
5
Oxycodone<0.1%16
6
Crizanlizumab-tmca<0.1%13
7
Ibuprofen<0.1%12
8
Folic-acid<0.1%12
9
Acetaminophen<0.1%11
10
Epoetin<0.1%10
11
Apixaban<0.1%8
12
Treprostinil<0.1%8
13
Dupilumab<0.1%7
14
Loperamide-hydrochloride<0.1%7
15
Tofacitinib<0.1%6

Taken alongside

1
Hydroxyurea8.5%1,905
2
Folic-acid6.5%1,439
3
Oxycodone2.6%588
4
Ergocalciferol2.3%520
5
Acetaminophen1.8%409
6
Deferasirox1.7%379
7
Ibuprofen1.5%334
8
Hydromorphone-hydrochloride1.0%227
9
L-glutamine1.0%224
10
Albuterol0.9%204
11
Gabapentin0.9%199
12
Hydrocodone0.7%157
13
Aspirin0.6%139
14
Fluticasone0.6%135
15
Morphine-sulfate0.6%133

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports voxelotor side effects

58.8% of voxelotor adverse event reports involve female patients and 39.0% involve male patients. The largest age group is adult at 75%. These figures reflect who reports side effects, not underlying risk.

Sex

Female58.8%
Male39.0%
Unknown2.1%

Age group

< 2<0.1%
2–117.4%
12–1714.2%
18–6475.2%
65+3.1%

What is voxelotor used for

Conditions and purposes for which patients were taking voxelotor when the adverse event was reported.

Acute Chest SyndromeAmerican TrypanosomiasisAnaemiaArthralgiaAstheniaAsthmaAbdominal MassAbdominal PainAcute Chest SyndromeAcute Kidney InjuryAnaemiaAnaemia ProphylaxisAnaemia Vitamin B12 DeficiencyAnxietyAplastic Anaemia

Showing 15 of 126 indications

Voxelotor brand names and reporting trend

Voxelotor is sold under the brand name Oxbryta.

Brand names

Oxbryta575

Quarterly reports (20102025)

2010202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking voxelotor with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.