OpenClaim

Vosoritide Side Effects

The most commonly reported side effects of vosoritide include injection site pain, injection site erythema, and pyrexia, based on 1,121 FDA adverse event reports from 2022 to 2025. 4.8% of reports found the drug to be ineffective.

#1 Reported: Injection Site PainAll side effects ↓Top Co-Medication: Elosulfase-alfaDrug interactions ↓68% of Reports Are ChildDemographics ↓

Vosoritide side effects

Percentages show how often each reaction appears relative to total reports for vosoritide.

1
Injection Site Pain15.1%169
2
Injection Site Erythema8.2%92
3
Pyrexia6.2%69
4
Injection Site Reaction5.3%59
5
Vomiting5.2%58
6
Drug Ineffective4.8%54
7
Injection Site Swelling4.6%52
8
Foramen Magnum Stenosis2.8%31
9
Off Label Use2.6%29
10
Injection Site Bruising2.6%29
11
Headache2.3%26
12
Ear Infection2.2%25
13
Injection Site Pruritus2.1%23
14
Fatigue1.9%21
15
Injection Site Urticaria1.9%21

These are voluntary reports and do not establish that vosoritide caused these reactions.

Report severity

25.7%Serious288 reports
11.5%Hospitalizations129 reports
0.5%Fatal6 reports

Seriousness is determined by the reporter, not by OpenClaim.

Vosoritide drug interactions

Other drugs that appear in adverse event reports alongside vosoritide. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Elosulfase-alfa0.3%3
2
Calcium-chloride<0.1%1
3
Dextrose<0.1%1
4
Magnesium-chloride<0.1%1
5
Sodium-acetate<0.1%1
6
Sodium-chloride<0.1%1
7
Leuprolide<0.1%1
8
Sulfamethoxazole<0.1%1
9
Trimethoprim<0.1%1
10
Ibuprofen<0.1%1
11
Ketoprofen<0.1%1
12
Diclofenac<0.1%1

Taken alongside

1
Fluticasone1.2%14
2
Cetirizine-hydrochloride0.7%8
3
Acetaminophen0.7%8
4
Albuterol0.7%8
5
Diphenhydramine0.6%7
6
Ibuprofen0.5%6
7
Ergocalciferol0.5%6
8
Montelukast-sodium0.5%6
9
Lidocaine0.5%6
10
Famotidine0.4%5
11
Polyethylene-glycol-33500.4%4
12
Prilocaine0.4%4
13
Oxygen0.4%4
14
Beclomethasone0.4%4
15
Oxcarbazepine0.3%3

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports vosoritide side effects

12.6% of vosoritide adverse event reports involve female patients and 12.8% involve male patients. The largest age group is child at 68%. These figures reflect who reports side effects, not underlying risk.

Sex

Female12.6%
Male12.8%
Unknown74.6%

Age group

< 220.2%
2–1167.8%
12–1711.3%
18–640.7%
65+0.0%

What is vosoritide used for

Conditions and purposes for which patients were taking vosoritide when the adverse event was reported.

Acromesomelic DysplasiaBone DisorderChondrodysplasia PunctataChondrodystrophyDisease SusceptibilityGene MutationGrowth DisorderHypochondroplasiaIllnessLimb Reduction DefectObstructive Sleep Apnoea SyndromeOsteochondrodysplasiaProduct Used For Unknown IndicationShort StatureThanatophoric Dysplasia

Vosoritide brand names and reporting trend

Vosoritide is sold under the brand name Voxzogo.

Brand names

Voxzogo1

Quarterly reports (2022–2025)

202220242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking vosoritide with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.

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