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Vorinostat Side Effects

The most commonly reported side effects of vorinostat include febrile neutropenia, product use in unapproved indication, and thrombocytopenia, based on 2,512 FDA adverse event reports from 2006 to 2025.

Vorinostat side effects

Percentages show how often each reaction appears relative to total reports for vorinostat.

1
Febrile Neutropenia9.0%227
2
Product Use In Unapproved Indication5.1%129
3
Thrombocytopenia4.8%121
4
Anaemia4.6%115
5
Platelet Count Decreased4.5%112
6
Nausea4.3%109
7
Off Label Use4.2%106
8
Sepsis4.0%100
9
Diarrhoea3.9%99
10
Fatigue3.6%91
11
Nausea3.6%90
12
Neutropenia3.4%86
13
Diarrhoea3.3%84
14
Thrombocytopenia3.3%83
15
Death3.3%82

These are voluntary reports and do not establish that vorinostat caused these reactions.

Report severity

88.4%Serious2,220 reports
51.8%Hospitalizations1,300 reports
20.1%Fatal504 reports

Seriousness is determined by the reporter, not by OpenClaim.

Vorinostat drug interactions

Other drugs that appear in adverse event reports alongside vorinostat. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Cyclophosphamide10.2%257
2
Bortezomib9.7%244
3
Vincristine-sulfate9.2%232
4
Azacitidine9.2%230
5
Doxorubicin-hydrochloride8.4%212
6
Dexamethasone8.4%211
7
Lenalidomide8.2%207
8
Cytarabine8.1%204
9
Decitabine7.8%196
10
Etoposide5.6%141
11
Rituximab5.6%141
12
Cisplatin5.5%139
13
Carboplatin4.9%124
14
Prednisone4.9%122
15
Methotrexate4.7%117

Taken alongside

1
Dexamethasone8.0%202
2
Ondansetron7.6%192
3
Acetaminophen5.9%149
4
Aspirin4.9%124
5
Omeprazole4.7%117
6
Acyclovir4.7%117
7
Oxycodone4.5%114
8
Levothyroxine-sodium3.8%95
9
Lorazepam3.7%94
10
Prochlorperazine3.4%85
11
Allopurinol3.1%79
12
Amlodipine3.1%78
13
Furosemide2.6%65
14
Metoprolol2.5%63
15
Diphenhydramine2.4%61

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports vorinostat side effects

38.5% of vorinostat adverse event reports involve female patients and 44.3% involve male patients. The largest age group is adult at 45%. These figures reflect who reports side effects, not underlying risk.

Sex

Female38.5%
Male44.3%
Unknown17.2%

Age group

< 25.0%
2–118.0%
12–175.0%
18–6445.4%
65+36.6%

What is vorinostat used for

Conditions and purposes for which patients were taking vorinostat when the adverse event was reported.

Acute LeukaemiaAcute Lymphocytic LeukaemiaAcute Lymphocytic Leukaemia RecurrentAcute Lymphocytic Leukaemia RefractoryAcute Megakaryocytic LeukaemiaAcute Monocytic LeukaemiaAcute Myeloid LeukaemiaAcute Myeloid Leukaemia RecurrentAcute Myeloid Leukaemia RefractoryAcute Myeloid LeukemiaAcute Myeloid Leukemia NosAdenocarcinomaAdenocarcinoma Of LungAdenocarcinoma PancreasAdult T-cell Lymphoma/leukaemia

Showing 15 of 264 indications

Vorinostat brand names and reporting trend

Vorinostat is sold under the brand name Zolinza.

Brand names

Zolinza2,834

Quarterly reports (20062025)

20062010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking vorinostat with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.