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Voriconazole Side Effects

The most commonly reported side effects of voriconazole include off label use, drug interaction, and pyrexia, based on 30,192 FDA adverse event reports from 2004 to 2025. 13.0% of reports found the drug to be ineffective.

Voriconazole side effects

Percentages show how often each reaction appears relative to total reports for voriconazole.

1
Drug Ineffective13.0%3,912
2
Off Label Use7.8%2,355
3
Drug Interaction6.9%2,085
4
Pyrexia3.9%1,183
5
Death3.9%1,179
6
Pneumonia3.6%1,096
7
Condition Aggravated3.2%958
8
Bronchopulmonary Aspergillosis3.0%894
9
Aspergillus Infection2.9%884
10
Febrile Neutropenia2.5%758
11
Product Use In Unapproved Indication2.4%724
12
Respiratory Failure2.2%668
13
Multiple Organ Dysfunction Syndrome2.2%656
14
Diarrhoea2.1%645
15
Nausea2.1%644

These are voluntary reports and do not establish that voriconazole caused these reactions.

Report severity

92.1%Serious27,820 reports
40.2%Hospitalizations12,130 reports
29.6%Fatal8,923 reports

Seriousness is determined by the reporter, not by OpenClaim.

Voriconazole drug interactions

Other drugs that appear in adverse event reports alongside voriconazole. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Amphotericin-b10.4%3,148
2
Tacrolimus7.3%2,189
3
Prednisone4.9%1,493
4
Mycophenolate4.9%1,491
5
Caspofungin-acetate4.2%1,255
6
Cyclosporine3.7%1,103
7
Cytarabine3.6%1,077
8
Prednisolone3.5%1,054
9
Cyclophosphamide3.5%1,044
10
Vancomycin3.3%1,001
11
Dexamethasone3.3%1,001
12
Meropenem3.1%921
13
Fluconazole3.0%892
14
Venetoclax2.9%872
15
Posaconazole2.9%868

Taken alongside

1
Acyclovir10.6%3,208
2
Prednisone7.7%2,331
3
Vancomycin7.3%2,205
4
Meropenem6.8%2,057
5
Sulfamethoxazole6.8%2,056
6
Amphotericin-b6.4%1,924
7
Acetaminophen5.8%1,746
8
Trimethoprim5.6%1,705
9
Tacrolimus5.6%1,701
10
Furosemide5.5%1,651
11
Levofloxacin5.4%1,645
12
Pantoprazole-sodium4.9%1,475
13
Ondansetron4.8%1,460
14
Omeprazole4.4%1,329
15
Methylprednisolone4.4%1,324

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports voriconazole side effects

34.8% of voriconazole adverse event reports involve female patients and 54.2% involve male patients. The largest age group is adult at 53%. These figures reflect who reports side effects, not underlying risk.

Sex

Female34.8%
Male54.2%
Unknown11.0%

Age group

< 21.5%
2–116.4%
12–175.1%
18–6452.6%
65+34.4%

What is voriconazole used for

Conditions and purposes for which patients were taking voriconazole when the adverse event was reported.

Abdominal AbscessAbdominal InfectionAbdominal PainAbdominal Pain UpperAbscessAbscess FungalAbscess JawAbscess LimbAcanthamoeba KeratitisAccidental OverdoseAcinetobacter InfectionAcinetobacter Test PositiveAcute Graft Versus Host Disease In LiverAcute LeukaemiaAcute Lymphocytic Leukaemia

Showing 15 of 1,144 indications

Voriconazole brand names and reporting trend

Voriconazole is sold under the brand name Vfend.

Brand names

Vfend29,324

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking voriconazole with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.