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Vorasidenib Side Effects

The most commonly reported side effects of vorasidenib include alanine aminotransferase increased, aspartate aminotransferase increased, and fatigue, based on 348 FDA adverse event reports from 2023 to 2025.

Vorasidenib side effects

Percentages show how often each reaction appears relative to total reports for vorasidenib.

1
Alanine Aminotransferase Increased12.6%44
2
Aspartate Aminotransferase Increased10.3%36
3
Fatigue9.5%33
4
Malignant Neoplasm Progression7.8%27
5
Nausea7.2%25
6
Headache7.2%25
7
Seizure7.2%25
8
Hepatic Enzyme Increased6.9%24
9
Hepatic Cytolysis6.6%23
10
Gamma-glutamyltransferase Increased5.7%20
11
Hepatotoxicity4.0%14
12
Drug-induced Liver Injury3.7%13
13
Diarrhoea3.7%13
14
Product Use Issue3.2%11
15
Fall2.9%10

These are voluntary reports and do not establish that vorasidenib caused these reactions.

Report severity

70.1%Serious244 reports
22.4%Hospitalizations78 reports
2.0%Fatal7 reports

Seriousness is determined by the reporter, not by OpenClaim.

Vorasidenib drug interactions

Other drugs that appear in adverse event reports alongside vorasidenib. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Bevacizumab2.3%8
2
Temozolomide1.7%6
3
Pembrolizumab1.1%4
4
Olaparib0.6%2
5
Ivosidenib0.6%2
6
Lomustine0.6%2
7
Olutasidenib0.3%1
8
Entrectinib0.3%1
9
Everolimus0.3%1
10
Abemaciclib0.3%1
11
Temsirolimus0.3%1
12
Nivolumab0.3%1
13
Larotrectinib-sulfate0.3%1
14
Futibatinib0.3%1
15
Selumetinib0.3%1

Taken alongside

1
Levetiracetam14.7%51
2
Lacosamide6.0%21
3
Lamotrigine3.4%12
4
Acetaminophen2.6%9
5
Ergocalciferol2.6%9
6
Ondansetron2.3%8
7
Dexamethasone1.7%6
8
Escitalopram-oxalate1.7%6
9
Amphetamine1.4%5
10
Lorazepam1.4%5
11
Aspirin1.4%5
12
Sertraline-hydrochloride1.4%5
13
Gabapentin1.4%5
14
Pantoprazole-sodium1.4%5
15
Levothyroxine-sodium1.1%4

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports vorasidenib side effects

0.9% of vorasidenib adverse event reports involve female patients and 2.3% involve male patients. The largest age group is adult at 75%. These figures reflect who reports side effects, not underlying risk.

Sex

Female0.9%
Male2.3%
Unknown96.8%

Age group

< 20.0%
2–110.0%
12–170.0%
18–6475.0%
65+25.0%

What is vorasidenib used for

Conditions and purposes for which patients were taking vorasidenib when the adverse event was reported.

AstrocytomaAstrocytoma MalignantAstrocytoma, Low GradeBladder CancerBone CancerBrain Cancer MetastaticBrain NeoplasmBrain Neoplasm MalignantCentral Nervous System NeoplasmCholangiocarcinomaGallbladder CancerGliomaIsocitrate Dehydrogenase Gene MutationLeukaemiaMalignant Oligodendroglioma

Showing 15 of 20 indications

Vorasidenib brand names and reporting trend

Vorasidenib is sold under the brand name Voranigo.

Brand names

Voranigo304

Quarterly reports (20232025)

20232025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking vorasidenib with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.