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Vorapaxar Side Effects

The most commonly reported side effects of vorapaxar include gastrointestinal haemorrhage, epistaxis, and drug dose omission, based on 199 FDA adverse event reports from 2013 to 2025. 2.0% of reports found the drug to be ineffective.

Vorapaxar side effects

Percentages show how often each reaction appears relative to total reports for vorapaxar.

1
Gastrointestinal Haemorrhage8.0%16
2
Epistaxis5.5%11
3
Drug Dose Omission4.0%8
4
Death4.0%8
5
Malaise3.5%7
6
Haemorrhage3.5%7
7
Chest Pain3.0%6
8
Pain In Extremity3.0%6
9
Rash2.5%5
10
Angina Pectoris2.0%4
11
Haemoglobin Decreased2.0%4
12
Back Pain2.0%4
13
Cerebrovascular Accident2.0%4
14
Anaemia2.0%4
15
Myocardial Infarction2.0%4

These are voluntary reports and do not establish that vorapaxar caused these reactions.

Report severity

39.7%Serious79 reports
21.1%Hospitalizations42 reports
6.0%Fatal12 reports

Seriousness is determined by the reporter, not by OpenClaim.

Vorapaxar drug interactions

Other drugs that appear in adverse event reports alongside vorapaxar. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Aspirin2.5%5
2
Evolocumab2.0%4
3
Lomitapide-mesylate2.0%4
4
Tasimelteon2.0%4
5
Ticagrelor1.5%3
6
Clopidogrel-bisulfate1.5%3
7
Natalizumab1.0%2
8
Insulin1.0%2
9
Rivaroxaban1.0%2
10
Dabigatran-etexilate-mesylate0.5%1
11
Sacubitril0.5%1
12
Valsartan0.5%1
13
Adalimumab0.5%1
14
Warfarin0.5%1
15
Albiglutide0.5%1

Taken alongside

1
Aspirin27.1%54
2
Clopidogrel-bisulfate16.6%33
3
Atorvastatin-calcium13.1%26
4
Amlodipine10.1%20
5
Metoprolol9.5%19
6
Ezetimibe8.0%16
7
Rosuvastatin8.0%16
8
Lisinopril8.0%16
9
Furosemide7.5%15
10
Pantoprazole-sodium5.5%11
11
Metformin5.5%11
12
Gabapentin5.0%10
13
Nitroglycerin5.0%10
14
Levothyroxine-sodium5.0%10
15
Carvedilol4.5%9

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports vorapaxar side effects

29.1% of vorapaxar adverse event reports involve female patients and 49.7% involve male patients. The largest age group is elderly at 68%. These figures reflect who reports side effects, not underlying risk.

Sex

Female29.1%
Male49.7%
Unknown21.1%

Age group

< 20.0%
2–110.0%
12–170.0%
18–6432.5%
65+67.5%

What is vorapaxar used for

Conditions and purposes for which patients were taking vorapaxar when the adverse event was reported.

Anticoagulant TherapyAntiplatelet TherapyArterial ThrombosisArteriosclerosis Coronary ArteryAtrial FibrillationCardiac DisorderCardiac FailureCardiac Failure CongestiveCardiac Rehabilitation TherapyCardiovascular DisorderCardiovascular Event ProphylaxisCoronary Artery DiseaseDecubitus UlcerDisseminated Intravascular CoagulationDressler^s Syndrome

Showing 15 of 30 indications

Vorapaxar brand names and reporting trend

Vorapaxar is sold under the brand name Zontivity.

Brand names

Zontivity2

Quarterly reports (20132025)

201320162025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking vorapaxar with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.