OpenClaim

Vonoprazan Side Effects

The most commonly reported side effects of vonoprazan include off label use, diarrhoea, and nausea, based on 6,580 FDA adverse event reports from 2014 to 2025. 6.1% of reports found the drug to be ineffective.

Vonoprazan side effects

Percentages show how often each reaction appears relative to total reports for vonoprazan.

1
Off Label Use6.7%443
2
Drug Ineffective6.1%403
3
Diarrhoea6.0%396
4
Nausea5.6%369
5
Decreased Appetite4.0%262
6
Malaise3.6%240
7
Pyrexia3.5%228
8
Gastrooesophageal Reflux Disease3.4%221
9
Interstitial Lung Disease2.9%192
10
Headache2.9%191
11
Anaemia2.8%183
12
Vomiting2.6%173
13
Pneumonia2.6%170
14
Abdominal Pain Upper2.6%170
15
Dizziness2.5%165

These are voluntary reports and do not establish that vonoprazan caused these reactions.

Report severity

73.6%Serious4,843 reports
44.9%Hospitalizations2,957 reports
14.2%Fatal936 reports

Seriousness is determined by the reporter, not by OpenClaim.

Vonoprazan drug interactions

Other drugs that appear in adverse event reports alongside vonoprazan. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Nivolumab4.9%320
2
Pembrolizumab2.9%193
3
Paclitaxel2.2%144
4
Atezolizumab2.2%142
5
Prednisolone2.1%140
6
Carboplatin2.0%132
7
Ipilimumab1.9%124
8
Bevacizumab1.7%112
9
Lenvatinib-mesylate1.7%109
10
Valsartan1.6%108
11
Prednisone1.5%97
12
Selexipag1.5%97
13
Durvalumab1.5%96
14
Sacubitril1.4%95
15
Upadacitinib1.3%87

Taken alongside

1
Amlodipine13.3%872
2
Magnesium-oxide12.3%812
3
Aspirin8.9%584
4
Furosemide8.0%527
5
Rosuvastatin7.6%502
6
Levothyroxine-sodium7.4%485
7
Prednisolone7.3%481
8
Febuxostat6.8%449
9
Bisoprolol-fumarate6.7%444
10
Spironolactone6.4%419
11
Acetaminophen5.9%385
12
Atorvastatin-calcium5.8%384
13
Prednisone4.9%322
14
Dexamethasone4.6%304
15
Pregabalin4.4%292

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports vonoprazan side effects

49.3% of vonoprazan adverse event reports involve female patients and 43.2% involve male patients. The largest age group is elderly at 61%. These figures reflect who reports side effects, not underlying risk.

Sex

Female49.3%
Male43.2%
Unknown7.5%

Age group

< 2<0.1%
2–11<0.1%
12–170.2%
18–6438.4%
65+61.3%

What is vonoprazan used for

Conditions and purposes for which patients were taking vonoprazan when the adverse event was reported.

Abdominal Pain UpperAngina PectorisAntacid TherapyAbdominal DiscomfortAbdominal DistensionAbdominal PainAbdominal Pain UpperAbnormal FaecesAcidosisAcute Lymphocytic LeukaemiaAcute Myocardial InfarctionAdenocarcinoma PancreasAdverse EventAnastomotic UlcerAngina Pectoris

Showing 15 of 228 indications

Vonoprazan brand names and reporting trend

Vonoprazan is sold under the brand name Voquezna Dual Pak.

Brand names

Voquezna Dual Pak5,270

Quarterly reports (20142025)

20142016202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking vonoprazan with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.