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Voclosporin Side Effects

The most commonly reported side effects of voclosporin include therapy interrupted, product dose omission issue, and hypertension, based on 7,261 FDA adverse event reports from 2017 to 2025.

Voclosporin side effects

Percentages show how often each reaction appears relative to total reports for voclosporin.

1
Therapy Interrupted12.9%939
2
Product Dose Omission Issue9.6%694
3
Hypertension8.6%624
4
Headache7.9%571
5
Nausea7.2%523
6
Diarrhoea6.2%452
7
Fatigue5.8%423
8
Proteinuria5.2%375
9
Vomiting3.9%283
10
Abdominal Discomfort3.7%266
11
Blood Pressure Increased3.6%259
12
Abdominal Pain Upper3.3%236
13
Covid-193.2%232
14
Off Label Use3.2%232
15
Glomerular Filtration Rate Decreased3.2%232

These are voluntary reports and do not establish that voclosporin caused these reactions.

Report severity

20.8%Serious1,508 reports
9.3%Hospitalizations678 reports
0.6%Fatal41 reports

Seriousness is determined by the reporter, not by OpenClaim.

Voclosporin drug interactions

Other drugs that appear in adverse event reports alongside voclosporin. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Mycophenolate3.1%224
2
Prednisone2.0%144
3
Belimumab0.8%56
4
Hydroxychloroquine-sulfate0.6%42
5
Rituximab0.3%23
6
Amlodipine0.3%23
7
Prednisolone0.3%19
8
Losartan-potassium0.2%18
9
Azathioprine0.2%18
10
Cyclophosphamide0.2%16
11
Lisinopril0.2%15
12
Methotrexate0.2%15
13
Dapagliflozin0.2%13
14
Anifrolumab-fnia0.2%13
15
Methylprednisolone0.2%11

Taken alongside

1
Prednisone8.0%581
2
Mycophenolate7.3%527
3
Hydroxychloroquine-sulfate6.8%497
4
Losartan-potassium2.9%210
5
Lisinopril2.8%206
6
Ergocalciferol2.5%180
7
Amlodipine2.2%160
8
Belimumab2.0%147
9
Furosemide1.6%116
10
Acetaminophen1.3%98
11
Omeprazole1.3%95
12
Atorvastatin-calcium1.3%92
13
Carvedilol1.2%85
14
Cholecalciferol1.1%79
15
Pantoprazole-sodium1.0%70

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports voclosporin side effects

82.5% of voclosporin adverse event reports involve female patients and 15.4% involve male patients. The largest age group is adult at 93%. These figures reflect who reports side effects, not underlying risk.

Sex

Female82.5%
Male15.4%
Unknown2.1%

Age group

< 2<0.1%
2–110.1%
12–171.9%
18–6492.6%
65+5.3%

What is voclosporin used for

Conditions and purposes for which patients were taking voclosporin when the adverse event was reported.

AtaxiaBrain Neoplasm MalignantCholeraChronic Kidney DiseaseConnective Tissue DisorderCryoglobulinaemiaDeathDyspepsiaGlomerular Vascular DisorderGastroenteritisGastrooesophageal Reflux DiseaseGlomerulonephritisGlomerulonephritis MembranoproliferativeGlomerulonephritis MembranousGlomerulonephritis Proliferative

Showing 15 of 48 indications

Voclosporin brand names and reporting trend

Voclosporin is sold under the brand name Lupkynis.

Brand names

Lupkynis103

Quarterly reports (20172025)

2017202220242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking voclosporin with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.