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Vitamin K Side Effects

The most commonly reported side effects of vitamin k include off label use, nausea, and fatigue, based on 8,199 FDA adverse event reports from 2004 to 2025. 5.8% of reports found the drug to be ineffective.

Vitamin K side effects

Percentages show how often each reaction appears relative to total reports for vitamin k.

1
Off Label Use7.2%589
2
Nausea6.5%529
3
Fatigue6.4%526
4
Drug Ineffective5.8%472
5
Dyspnoea5.1%422
6
Vomiting4.8%395
7
Diarrhoea4.8%391
8
Headache4.7%385
9
Pain3.9%319
10
Abdominal Pain3.7%307
11
Arthralgia3.6%295
12
Constipation3.6%294
13
Condition Aggravated3.6%294
14
Pyrexia3.3%270
15
Asthenia3.3%267

These are voluntary reports and do not establish that vitamin k caused these reactions.

Report severity

75.7%Serious6,205 reports
42.1%Hospitalizations3,450 reports
16.2%Fatal1,330 reports

Seriousness is determined by the reporter, not by OpenClaim.

Vitamin K drug interactions

Other drugs that appear in adverse event reports alongside vitamin k. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Acetaminophen4.4%361
2
Warfarin4.3%352
3
Ascorbic-acid4.3%352
4
Ivacaftor4.0%331
5
Ceftriaxone-sodium4.0%329
6
Heparin3.8%310
7
Pyridoxine3.8%309
8
Lenalidomide3.5%288
9
Albuterol3.3%274
10
Metronidazole3.3%267
11
Lansoprazole3.3%267
12
Biotin3.2%264
13
Potassium-chloride3.2%259
14
Riboflavin3.1%258
15
Ondansetron3.0%250

Taken alongside

1
Ergocalciferol33.9%2,780
2
Acetaminophen17.9%1,469
3
Calcium13.4%1,099
4
Ascorbic-acid12.9%1,055
5
Furosemide12.7%1,041
6
Albuterol11.6%948
7
Omeprazole11.4%934
8
Aspirin11.1%907
9
Magnesium-acetate-tetrahydrate10.4%852
10
Levothyroxine-sodium9.2%757
11
Pantoprazole-sodium8.7%713
12
Cyanocobalamin8.6%703
13
Ondansetron7.9%649
14
Vitamin-e7.8%637
15
Potassium-chloride7.6%624

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports vitamin k side effects

53.3% of vitamin k adverse event reports involve female patients and 39.5% involve male patients. The largest age group is adult at 46%. These figures reflect who reports side effects, not underlying risk.

Sex

Female53.3%
Male39.5%
Unknown7.3%

Age group

< 26.0%
2–114.5%
12–174.2%
18–6446.0%
65+39.3%

What is vitamin k used for

Conditions and purposes for which patients were taking vitamin k when the adverse event was reported.

Abnormal Clotting FactorAcquired Von Willebrand^s DiseaseActivated Partial Thromboplastin TimeActivated Partial Thromboplastin Time ProlongedAcute Hepatic FailureAcute Kidney InjuryAdjuvant TherapyAdverse EventAlagille SyndromeAlcoholic Liver DiseaseAnaemiaAngiopathyAnticoagulant TherapyAnticoagulation Drug Level Above TherapeuticAntiinflammatory Therapy

Showing 15 of 417 indications

Vitamin K brand names and reporting trend

Vitamin K is sold under the brand name Infuvite Adult.

Brand names

Infuvite Adult8,943

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking vitamin k with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.