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Vitamin E Side Effects

The most commonly reported side effects of vitamin e include fatigue, diarrhoea, and nausea, based on 39,173 FDA adverse event reports from 2004 to 2025. 4.9% of reports found the drug to be ineffective.

Vitamin E side effects

Percentages show how often each reaction appears relative to total reports for vitamin e.

1
Fatigue6.7%2,634
2
Diarrhoea5.5%2,169
3
Nausea5.3%2,094
4
Drug Ineffective4.9%1,926
5
Headache4.7%1,856
6
Pain4.3%1,686
7
Arthralgia3.8%1,470
8
Dyspnoea3.7%1,464
9
Dizziness3.7%1,444
10
Off Label Use3.5%1,365
11
Weight Decreased3.2%1,263
12
Fall3.2%1,263
13
Asthenia3.2%1,260
14
Vomiting2.7%1,051
15
Pain In Extremity2.6%1,031

These are voluntary reports and do not establish that vitamin e caused these reactions.

Report severity

57.1%Serious22,386 reports
27.5%Hospitalizations10,756 reports
5.3%Fatal2,089 reports

Seriousness is determined by the reporter, not by OpenClaim.

Vitamin E drug interactions

Other drugs that appear in adverse event reports alongside vitamin e. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Adalimumab5.0%1,978
2
Lenalidomide4.5%1,758
3
Niacin3.0%1,156
4
Lomitapide-mesylate2.2%846
5
Etanercept2.1%814
6
Sodium-oxybate2.0%772
7
Aspirin1.7%662
8
Esomeprazole1.5%603
9
Ivacaftor1.5%591
10
Dalfampridine1.5%572
11
Omeprazole1.5%571
12
Pregabalin1.4%560
13
Fluticasone1.4%551
14
Teriparatide1.4%542
15
Acetaminophen1.3%503

Taken alongside

1
Ergocalciferol49.4%19,344
2
Ascorbic-acid38.6%15,137
3
Aspirin28.3%11,096
4
Cyanocobalamin23.9%9,366
5
Calcium21.7%8,508
6
Folic-acid20.6%8,060
7
Acetaminophen18.3%7,151
8
Fish17.0%6,677
9
Levothyroxine-sodium16.3%6,388
10
Biotin15.3%6,013
11
Vitamin-a14.7%5,746
12
Omeprazole13.4%5,239
13
Metoprolol11.4%4,450
14
Atorvastatin-calcium11.4%4,449
15
Albuterol11.3%4,412

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports vitamin e side effects

63.4% of vitamin e adverse event reports involve female patients and 31.6% involve male patients. The largest age group is elderly at 50%. These figures reflect who reports side effects, not underlying risk.

Sex

Female63.4%
Male31.6%
Unknown4.9%

Age group

< 20.3%
2–110.9%
12–171.2%
18–6447.9%
65+49.7%

What is vitamin e used for

Conditions and purposes for which patients were taking vitamin e when the adverse event was reported.

Abdominal DiscomfortAbdominal DistensionAbdominal Wall DisorderAcneAdjuvant TherapyAdverse Drug ReactionAdverse EventAmyotrophic Lateral SclerosisAnaemiaAngiopathyAnticoagulant TherapyAntiinflammatory TherapyAntioxidant TherapyAntiviral ProphylaxisArterial Disorder

Showing 15 of 435 indications

Vitamin E brand names and reporting trend

Vitamin E is sold under the brand name M.v.i.-12 Adult.

Brand names

M.v.i.-12 Adult36,045

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking vitamin e with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.