OpenClaim

Vismodegib Side Effects

The most commonly reported side effects of vismodegib include muscle spasms, alopecia, and ageusia, based on 8,719 FDA adverse event reports from 2012 to 2025. 2.2% of reports found the drug to be ineffective.

Vismodegib side effects

Percentages show how often each reaction appears relative to total reports for vismodegib.

1
Muscle Spasms23.2%2,023
2
Alopecia15.9%1,384
3
Ageusia11.4%994
4
Fatigue10.9%954
5
Dysgeusia8.5%739
6
Weight Decreased8.4%731
7
Death8.4%729
8
Nausea8.1%702
9
Decreased Appetite8.0%696
10
Diarrhoea5.4%469
11
Constipation4.3%378
12
Off Label Use4.2%365
13
Asthenia3.3%290
14
Arthralgia3.2%276
15
Vomiting2.9%256

These are voluntary reports and do not establish that vismodegib caused these reactions.

Report severity

42.7%Serious3,726 reports
13.1%Hospitalizations1,141 reports
11.1%Fatal969 reports

Seriousness is determined by the reporter, not by OpenClaim.

Vismodegib drug interactions

Other drugs that appear in adverse event reports alongside vismodegib. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Gemcitabine0.8%68
2
Erlotinib-hydrochloride0.7%63
3
Etoposide0.7%62
4
Cisplatin0.6%55
5
Sonidegib-phosphate0.3%26
6
Paclitaxel0.3%24
7
Venetoclax0.3%24
8
Furosemide0.2%21
9
Bevacizumab0.2%20
10
Itraconazole0.2%17
11
Irinotecan-hydrochloride0.2%16
12
Temozolomide0.2%16
13
Ruxolitinib0.2%16
14
Carboplatin0.2%16
15
Cemiplimab-rwlc0.2%16

Taken alongside

1
Aspirin4.8%422
2
Amlodipine4.4%383
3
Atorvastatin-calcium4.3%371
4
Acetaminophen4.2%370
5
Lisinopril3.9%340
6
Metoprolol3.8%327
7
Levothyroxine-sodium3.6%312
8
Furosemide3.1%274
9
Omeprazole2.9%252
10
Gabapentin2.6%223
11
Simvastatin2.5%221
12
Metformin2.3%199
13
Tamsulosin-hydrochloride2.1%186
14
Losartan-potassium2.0%173
15
Ergocalciferol1.9%169

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports vismodegib side effects

36.5% of vismodegib adverse event reports involve female patients and 56.0% involve male patients. The largest age group is elderly at 68%. These figures reflect who reports side effects, not underlying risk.

Sex

Female36.5%
Male56.0%
Unknown7.5%

Age group

< 2<0.1%
2–110.3%
12–170.3%
18–6431.4%
65+67.8%

What is vismodegib used for

Conditions and purposes for which patients were taking vismodegib when the adverse event was reported.

Abnormal BehaviourActinic KeratosisAcute Myeloid LeukaemiaAdenocarcinomaAdenocarcinoma Of ColonAdenocarcinoma PancreasAdenoid Cystic CarcinomaAdenosquamous Cell CarcinomaAdrenal Gland CancerAgranulocytosisAlport^s SyndromeAnal Cancer MetastaticArteriosclerosis Coronary ArteryArthralgiaArthritis

Showing 15 of 349 indications

Vismodegib brand names and reporting trend

Vismodegib is sold under the brand name Erivedge.

Brand names

Erivedge1,310

Quarterly reports (20122025)

20122016202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking vismodegib with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.