OpenClaim

Vincristine Side Effects

The most commonly reported side effects of vincristine include febrile neutropenia, off label use, and neutropenia, based on 104,180 FDA adverse event reports from 2004 to 2025. 4.7% of reports found the drug to be ineffective.

#1 Reported: Febrile NeutropeniaAll side effects ↓Top Co-Medication: CyclophosphamideDrug interactions ↓45% of Reports Are AdultDemographics ↓

Vincristine side effects

Percentages show how often each reaction appears relative to total reports for vincristine.

1
Febrile Neutropenia9.7%10,099
2
Off Label Use7.8%8,109
3
Neutropenia5.7%5,902
4
Disease Progression5.6%5,838
5
Drug Ineffective4.7%4,900
6
Pyrexia4.2%4,348
7
Thrombocytopenia3.4%3,548
8
Sepsis3.3%3,390
9
Product Use In Unapproved Indication3.2%3,380
10
Anaemia3.1%3,215
11
Death3.0%3,176
12
Pneumonia2.9%3,019
13
Pancytopenia2.4%2,518
14
Nausea2.4%2,450
15
Vomiting2.2%2,328

These are voluntary reports and do not establish that vincristine caused these reactions.

Report severity

97.0%Serious101,100 reports
38.0%Hospitalizations39,557 reports
21.0%Fatal21,896 reports

Seriousness is determined by the reporter, not by OpenClaim.

Vincristine drug interactions

Other drugs that appear in adverse event reports alongside vincristine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Cyclophosphamide58.0%60,380
2
Doxorubicin-hydrochloride54.8%57,131
3
Rituximab39.9%41,545
4
Prednisone36.3%37,854
5
Methotrexate26.7%27,853
6
Etoposide21.3%22,186
7
Dexamethasone20.3%21,183
8
Cytarabine20.1%20,935
9
Prednisolone14.9%15,517
10
Pegaspargase7.8%8,123
11
Cisplatin7.6%7,875
12
Ifosfamide7.5%7,805
13
Mercaptopurine7.1%7,392
14
Daunorubicin6.9%7,239
15
Carboplatin6.3%6,611

Taken alongside

1
Cyclophosphamide10.8%11,240
2
Doxorubicin-hydrochloride9.1%9,471
3
Prednisone7.5%7,798
4
Dexamethasone5.7%5,971
5
Sulfamethoxazole5.0%5,216
6
Acetaminophen4.9%5,127
7
Ondansetron4.7%4,858
8
Trimethoprim4.5%4,709
9
Methotrexate4.3%4,456
10
Allopurinol3.8%3,936
11
Acyclovir3.7%3,832
12
Rituximab3.7%3,819
13
Prednisolone3.6%3,758
14
Cytarabine3.3%3,403
15
Etoposide3.2%3,348

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports vincristine side effects

33.6% of vincristine adverse event reports involve female patients and 44.0% involve male patients. The largest age group is adult at 45%. These figures reflect who reports side effects, not underlying risk.

Sex

Female33.6%
Male44.0%
Unknown22.4%

Age group

< 23.7%
2–1116.7%
12–178.4%
18–6445.4%
65+25.8%

What is vincristine used for

Conditions and purposes for which patients were taking vincristine when the adverse event was reported.

5q Minus Syndrome5q Minus SyndromeAbdominal LymphadenopathyAbdominal MassAbdominal NeoplasmAbdominal PainAccidental ExposureAcquired HaemophiliaAcquired Haemophilia With Anti Fviii, Xi, Or XiiiAcquired Immunodeficiency SyndromeAcute Biphenotypic LeukaemiaAcute Kidney InjuryAcute LeukaemiaAcute Leukaemia In RemissionAcute Lymphoblastic Leukaemia

Showing 15 of 1,732 indications

Vincristine brand names and reporting trend

Vincristine is sold under the brand name Oncovin.

Brand names

Oncovin121,136

Quarterly reports (2004–2025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking vincristine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.

Check my medications