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Vinblastine Side Effects

The most commonly reported side effects of vinblastine include off label use, febrile neutropenia, and neutropenia, based on 7,621 FDA adverse event reports from 2004 to 2025. 4.8% of reports found the drug to be ineffective.

Vinblastine side effects

Percentages show how often each reaction appears relative to total reports for vinblastine.

1
Off Label Use9.0%684
2
Febrile Neutropenia7.4%561
3
Neutropenia6.2%472
4
Drug Ineffective4.8%368
5
Pyrexia4.1%313
6
Disease Progression4.0%304
7
Product Use In Unapproved Indication4.0%304
8
Neuropathy Peripheral3.9%294
9
Nausea3.5%263
10
Vomiting2.9%222
11
Diarrhoea2.8%211
12
Hodgkin^s Disease2.7%204
13
Anaemia2.7%204
14
Thrombocytopenia2.6%197
15
Malignant Neoplasm Progression2.5%190

These are voluntary reports and do not establish that vinblastine caused these reactions.

Report severity

94.6%Serious7,209 reports
31.2%Hospitalizations2,376 reports
19.4%Fatal1,482 reports

Seriousness is determined by the reporter, not by OpenClaim.

Vinblastine drug interactions

Other drugs that appear in adverse event reports alongside vinblastine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Doxorubicin-hydrochloride67.0%5,104
2
Dacarbazine53.4%4,067
3
Bleomycin-sulfate40.5%3,088
4
Brentuximab-vedotin23.2%1,766
5
Vincristine-sulfate16.7%1,271
6
Etoposide16.2%1,234
7
Cyclophosphamide14.5%1,106
8
Cisplatin14.0%1,067
9
Prednisone13.0%987
10
Methotrexate10.7%812
11
Procarbazine-hydrochloride10.5%800
12
Carboplatin7.4%567
13
Prednisolone7.3%557
14
Cytarabine7.0%531
15
Dexamethasone6.7%508

Taken alongside

1
Doxorubicin-hydrochloride10.8%825
2
Dacarbazine9.6%730
3
Bleomycin-sulfate6.3%478
4
Dexamethasone3.7%280
5
Ondansetron3.4%258
6
Prednisone2.9%223
7
Cisplatin2.9%223
8
Methotrexate2.8%211
9
Acyclovir2.0%156
10
Acetaminophen2.0%153
11
Cyclophosphamide2.0%151
12
Filgrastim2.0%149
13
Etoposide1.7%128
14
Sulfamethoxazole1.5%116
15
Trimethoprim1.5%111

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports vinblastine side effects

33.2% of vinblastine adverse event reports involve female patients and 42.4% involve male patients. The largest age group is adult at 61%. These figures reflect who reports side effects, not underlying risk.

Sex

Female33.2%
Male42.4%
Unknown24.4%

Age group

< 24.7%
2–118.2%
12–175.2%
18–6460.9%
65+21.1%

What is vinblastine used for

Conditions and purposes for which patients were taking vinblastine when the adverse event was reported.

Accidental ExposureAccidental Exposure To ProductAcquired Immunodeficiency SyndromeAcute Lymphocytic LeukaemiaAcute Lymphocytic Leukaemia RecurrentAcute Lymphocytic Leukaemia RefractoryAcute Myeloid LeukaemiaAcute Myeloid Leukaemia RecurrentAdenocarcinomaAdenocarcinoma GastricAdenomatous Polyposis ColiAdult T-cell Lymphoma/leukaemiaAnaemiaAnal CancerAnaplastic Large Cell Lymphoma T- And Null-cell Types

Showing 15 of 481 indications

Vinblastine brand names and reporting trend

Vinblastine is sold under the brand name Vinblastine Sulfate.

Brand names

Vinblastine Sulfate8,527

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking vinblastine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.