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Vimseltinib Side Effects

The most commonly reported side effects of vimseltinib include fatigue, swelling face, and pruritus, based on 306 FDA adverse event reports from 2021 to 2025.

Vimseltinib side effects

Percentages show how often each reaction appears relative to total reports for vimseltinib.

1
Fatigue28.8%88
2
Swelling Face13.1%40
3
Pruritus12.1%37
4
Periorbital Swelling11.1%34
5
Peripheral Swelling10.5%32
6
Headache8.8%27
7
Nausea8.8%27
8
Rash8.8%27
9
Eye Swelling8.2%25
10
Product Dose Omission Issue7.2%22
11
Arthralgia5.9%18
12
Hepatic Enzyme Increased5.6%17
13
Pain4.6%14
14
Periorbital Oedema4.2%13
15
Blood Creatine Phosphokinase Increased4.2%13

These are voluntary reports and do not establish that vimseltinib caused these reactions.

Report severity

11.8%Serious36 reports
3.3%Hospitalizations10 reports
0.3%Fatal1 reports

Seriousness is determined by the reporter, not by OpenClaim.

Vimseltinib drug interactions

Other drugs that appear in adverse event reports alongside vimseltinib. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Avelumab0.3%1
2
Pexidartinib-hydrochloride0.3%1
3
Nirogacestat-hydrobromide0.3%1
4
Progesterone0.3%1
5
Drospirenone0.3%1
6
Ethinyl-estradiol0.3%1
7
Venlafaxine0.3%1

Taken alongside

1
Ergocalciferol3.3%10
2
Acetaminophen2.9%9
3
Ibuprofen2.9%9
4
Aspirin2.0%6
5
Rosuvastatin1.6%5
6
Levothyroxine-sodium1.3%4
7
Losartan-potassium1.3%4
8
Ascorbic-acid1.3%4
9
Gabapentin1.3%4
10
Ethinyl-estradiol1.3%4
11
Norethindrone1.3%4
12
Cyanocobalamin1.3%4
13
Amlodipine1.0%3
14
Hydrochlorothiazide1.0%3
15
Naproxen1.0%3

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports vimseltinib side effects

60.8% of vimseltinib adverse event reports involve female patients and 35.0% involve male patients. The largest age group is adult at 91%. These figures reflect who reports side effects, not underlying risk.

Sex

Female60.8%
Male35.0%
Unknown4.2%

Age group

< 20.0%
2–110.0%
12–170.3%
18–6490.9%
65+8.7%

What is vimseltinib used for

Conditions and purposes for which patients were taking vimseltinib when the adverse event was reported.

Benign Connective Tissue NeoplasmBenign Soft Tissue NeoplasmBone NeoplasmCartilage NeoplasmChemotherapyConnective Tissue NeoplasmDesmoid TumourGiant Cell Tumour Of Tendon SheathGiant Cell Tumour Of Tendon SheathHistiocytosisHyperplasiaJoint DislocationLeiomyosarcomaMalignant Connective Tissue NeoplasmNeoplasm

Showing 15 of 22 indications

Vimseltinib brand names and reporting trend

Vimseltinib is sold under the brand name Romvimza.

Brand names

Romvimza40

Quarterly reports (20212025)

20212025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking vimseltinib with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.