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Vestronidase Side Effects

The most commonly reported side effects of vestronidase include cough, infective pulmonary exacerbation of cystic fibrosis, and dyspnoea, based on 80 FDA adverse event reports from 2013 to 2025.

Vestronidase side effects

Percentages show how often each reaction appears relative to total reports for vestronidase.

1
Cough11.3%9
2
Infective Pulmonary Exacerbation Of Cystic Fibrosis10.0%8
3
Dyspnoea7.5%6
4
Rash6.3%5
5
Vomiting5.0%4
6
Fall5.0%4
7
Pneumonia5.0%4
8
Pyrexia5.0%4
9
Product Dose Omission Issue5.0%4
10
Productive Cough3.8%3
11
Malaise3.8%3
12
Dysphonia3.8%3
13
Influenza Like Illness3.8%3
14
Respiratory Failure3.8%3
15
Swelling3.8%3

These are voluntary reports and do not establish that vestronidase caused these reactions.

Report severity

62.5%Serious50 reports
35.0%Hospitalizations28 reports
7.5%Fatal6 reports

Seriousness is determined by the reporter, not by OpenClaim.

Vestronidase drug interactions

Other drugs that appear in adverse event reports alongside vestronidase. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Tobramycin12.5%10
2
Aztreonam3.8%3
3
Colistin-sulfate2.5%2
4
Risperidone2.5%2
5
Umeclidinium-bromide1.3%1
6
Vilanterol-trifenatate1.3%1
7
Tipiracil1.3%1
8
Trifluridine1.3%1
9
Tiotropium-bromide1.3%1
10
Bosentan1.3%1
11
Crisaborole1.3%1
12
Elexacaftor-ivacaftor-tezacaftor1.3%1
13
Ivacaftor1.3%1
14
Ergocalciferol1.3%1
15
Clofazimine1.3%1

Taken alongside

1
Albuterol35.0%28
2
Sodium-chloride27.5%22
3
Diphenhydramine22.5%18
4
Epinephrine21.3%17
5
Heparin20.0%16
6
Acetaminophen17.5%14
7
Dornase-alfa15.0%12
8
Budesonide15.0%12
9
Fluticasone13.8%11
10
Lidocaine13.8%11
11
Loratadine12.5%10
12
Ammonium12.5%10
13
Azithromycin12.5%10
14
Lipase11.3%9
15
Pancrelipase-amylase11.3%9

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports vestronidase side effects

53.8% of vestronidase adverse event reports involve female patients and 37.5% involve male patients. The largest age group is adolescent at 33%. These figures reflect who reports side effects, not underlying risk.

Sex

Female53.8%
Male37.5%
Unknown8.8%

Age group

< 27.7%
2–1125.0%
12–1732.7%
18–6425.0%
65+9.6%

What is vestronidase used for

Conditions and purposes for which patients were taking vestronidase when the adverse event was reported.

Airway Secretion Clearance TherapyBronchiectasisCystic Fibrosis LungLabyrinthitisLung DisorderMucopolysaccharidosisMucopolysaccharidosis ViiMucopolysaccharidosisMucopolysaccharidosis ViiProduct Used For Unknown IndicationProduct Used For Unknown IndicationPulmonary Arterial Hypertension

Vestronidase brand names and reporting trend

Vestronidase is sold under the brand name Mepsevii.

Brand names

Mepsevii30

Quarterly reports (20132025)

2013202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking vestronidase with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.