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Vericiguat Side Effects

The most commonly reported side effects of vericiguat include hypotension, cardiac failure, and death, based on 1,108 FDA adverse event reports from 2015 to 2025.

Vericiguat side effects

Percentages show how often each reaction appears relative to total reports for vericiguat.

1
Hypotension11.1%123
2
Cardiac Failure9.8%109
3
Death9.4%104
4
Dizziness6.7%74
5
Product Dose Omission Issue4.5%50
6
No Adverse Event4.0%44
7
Dyspnoea3.5%39
8
Blood Pressure Decreased3.5%39
9
Anaemia3.3%37
10
Fatigue3.3%37
11
Malaise3.3%37
12
Nausea2.8%31
13
Asthenia2.6%29
14
Diarrhoea2.6%29
15
Product Use Issue2.5%28

These are voluntary reports and do not establish that vericiguat caused these reactions.

Report severity

57.0%Serious632 reports
28.1%Hospitalizations311 reports
16.8%Fatal186 reports

Seriousness is determined by the reporter, not by OpenClaim.

Vericiguat drug interactions

Other drugs that appear in adverse event reports alongside vericiguat. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Valsartan3.3%37
2
Sacubitril3.2%35
3
Rivaroxaban1.6%18
4
Dapagliflozin1.6%18
5
Empagliflozin1.1%12
6
Treprostinil1.0%11
7
Tolvaptan0.6%7
8
Furosemide0.5%6
9
Amiodarone-hydrochloride0.5%6
10
Edoxaban0.5%6
11
Tadalafil0.5%6
12
Macitentan0.5%5
13
Lenalidomide0.5%5
14
Riociguat0.5%5
15
Spironolactone0.4%4

Taken alongside

1
Valsartan13.6%151
2
Sacubitril13.5%150
3
Furosemide11.8%131
4
Spironolactone9.5%105
5
Carvedilol8.5%94
6
Dapagliflozin6.7%74
7
Bisoprolol-fumarate6.6%73
8
Empagliflozin5.5%61
9
Atorvastatin-calcium5.3%59
10
Aspirin5.1%57
11
Levothyroxine-sodium3.7%41
12
Tolvaptan3.7%41
13
Metoprolol3.7%41
14
Apixaban3.6%40
15
Amiodarone-hydrochloride3.5%39

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports vericiguat side effects

30.5% of vericiguat adverse event reports involve female patients and 60.6% involve male patients. The largest age group is elderly at 78%. These figures reflect who reports side effects, not underlying risk.

Sex

Female30.5%
Male60.6%
Unknown8.9%

Age group

< 20.0%
2–110.0%
12–170.0%
18–6421.9%
65+78.1%

What is vericiguat used for

Conditions and purposes for which patients were taking vericiguat when the adverse event was reported.

Angina PectorisArrhythmiaArteriosclerosis Coronary ArteryAtrial FibrillationCardiac FailureCardiac Failure CongestiveCardiac DisorderCardiac FailureCardiac Failure AcuteCardiac Failure ChronicCardiac Failure CongestiveCardiomyopathyCardiothoracic Ratio IncreasedCardiovascular DisorderCardiovascular Event Prophylaxis

Showing 15 of 44 indications

Vericiguat brand names and reporting trend

Vericiguat is sold under the brand name Verquvo.

Brand names

Verquvo416

Quarterly reports (20152025)

201520242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking vericiguat with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.