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Vemurafenib Side Effects

The most commonly reported side effects of vemurafenib include rash, arthralgia, and fatigue, based on 11,922 FDA adverse event reports from 2006 to 2025.

Vemurafenib side effects

Percentages show how often each reaction appears relative to total reports for vemurafenib.

1
Rash12.1%1,447
2
Arthralgia7.9%943
3
Fatigue7.8%928
4
Death7.6%902
5
Off Label Use7.1%842
6
Diarrhoea6.5%774
7
Nausea6.1%733
8
Pyrexia5.8%696
9
Disease Progression5.7%683
10
Alopecia4.4%527
11
Decreased Appetite4.0%479
12
Vomiting3.6%431
13
Photosensitivity Reaction3.3%398
14
Pruritus3.0%360
15
No Adverse Event2.9%346

These are voluntary reports and do not establish that vemurafenib caused these reactions.

Report severity

74.7%Serious8,900 reports
28.4%Hospitalizations3,387 reports
17.3%Fatal2,062 reports

Seriousness is determined by the reporter, not by OpenClaim.

Vemurafenib drug interactions

Other drugs that appear in adverse event reports alongside vemurafenib. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Cobimetinib-fumarate23.0%2,740
2
Atezolizumab2.3%269
3
Dabrafenib-mesylate2.2%262
4
Ipilimumab1.7%205
5
Trametinib1.6%195
6
Nivolumab1.6%190
7
Rituximab1.1%131
8
Pembrolizumab0.9%106
9
Bevacizumab0.8%94
10
Cetuximab0.7%86
11
Irinotecan-hydrochloride0.7%86
12
Dexamethasone0.6%74
13
Fluorouracil0.6%69
14
Capecitabine0.6%68
15
Oxaliplatin0.5%64

Taken alongside

1
Acetaminophen3.9%463
2
Levothyroxine-sodium2.8%334
3
Omeprazole2.7%325
4
Prednisone2.7%321
5
Pantoprazole-sodium2.5%300
6
Dexamethasone2.5%297
7
Aspirin2.4%284
8
Oxycodone2.4%282
9
Amlodipine2.2%266
10
Ondansetron2.0%233
11
Ibuprofen1.9%222
12
Atorvastatin-calcium1.7%202
13
Metformin1.7%198
14
Furosemide1.6%193
15
Levetiracetam1.6%187

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports vemurafenib side effects

39.3% of vemurafenib adverse event reports involve female patients and 50.7% involve male patients. The largest age group is adult at 58%. These figures reflect who reports side effects, not underlying risk.

Sex

Female39.3%
Male50.7%
Unknown10.0%

Age group

< 20.8%
2–111.4%
12–170.8%
18–6458.2%
65+38.8%

What is vemurafenib used for

Conditions and purposes for which patients were taking vemurafenib when the adverse event was reported.

Acral Lentiginous MelanomaAcral Lentiginous Melanoma Stage IvAcute LeukaemiaAdenocarcinomaAdenocarcinoma Of ColonAdenocarcinoma Of The CervixAdrenal Gland CancerAlopecia AreataAlopecia ScarringAnaemiaAnaplastic AstrocytomaAnaplastic Thyroid CancerAnxiety DisorderAppendix CancerArthralgia

Showing 15 of 401 indications

Vemurafenib brand names and reporting trend

Vemurafenib is sold under the brand name Zelboraf.

Brand names

Zelboraf5,745

Quarterly reports (20062025)

2006201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking vemurafenib with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.