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Velpatasvir Side Effects

The most commonly reported side effects of velpatasvir include fatigue, headache, and nausea, based on 15,135 FDA adverse event reports from 2015 to 2025. 4.2% of reports found the drug to be ineffective.

Velpatasvir side effects

Percentages show how often each reaction appears relative to total reports for velpatasvir.

1
Fatigue21.1%3,188
2
Headache17.8%2,699
3
Nausea9.5%1,445
4
Diarrhoea5.5%828
5
Drug Ineffective4.2%642
6
Insomnia4.1%618
7
Product Dose Omission Issue3.3%501
8
Hepatitis C3.2%489
9
Treatment Failure2.8%430
10
Vomiting2.7%406
11
Intentional Dose Omission2.6%389
12
Dizziness2.3%341
13
Product Dose Omission2.2%330
14
Abdominal Discomfort2.0%309
15
Death2.0%300

These are voluntary reports and do not establish that velpatasvir caused these reactions.

Report severity

28.1%Serious4,260 reports
9.8%Hospitalizations1,483 reports
3.9%Fatal594 reports

Seriousness is determined by the reporter, not by OpenClaim.

Velpatasvir drug interactions

Other drugs that appear in adverse event reports alongside velpatasvir. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Sofosbuvir87.1%13,177
2
Voxilaprevir7.0%1,055
3
Ribavirin4.7%710
4
Tenofovir0.5%72
5
Daclatasvir-dihydrochloride0.4%60
6
Ledipasvir0.4%54
7
Emtricitabine0.3%50
8
Pibrentasvir0.2%37
9
Tacrolimus0.2%34
10
Mycophenolate0.2%32
11
Glecaprevir0.2%32
12
Prednisone0.2%27
13
Grazoprevir0.1%21
14
Atezolizumab0.1%20
15
Metformin0.1%19

Taken alongside

1
Lisinopril3.5%526
2
Gabapentin3.4%517
3
Amlodipine3.3%505
4
Furosemide3.0%456
5
Omeprazole2.9%435
6
Aspirin2.7%408
7
Albuterol2.6%395
8
Acetaminophen2.4%357
9
Ibuprofen2.3%342
10
Ergocalciferol2.2%338
11
Spironolactone2.2%330
12
Metformin2.1%313
13
Sofosbuvir2.0%308
14
Metoprolol1.8%279
15
Atorvastatin-calcium1.8%274

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports velpatasvir side effects

40.5% of velpatasvir adverse event reports involve female patients and 55.8% involve male patients. The largest age group is adult at 80%. These figures reflect who reports side effects, not underlying risk.

Sex

Female40.5%
Male55.8%
Unknown3.7%

Age group

< 2<0.1%
2–110.3%
12–17<0.1%
18–6480.3%
65+19.3%

What is velpatasvir used for

Conditions and purposes for which patients were taking velpatasvir when the adverse event was reported.

Acute Hepatitis BAcute Hepatitis CAlanine Aminotransferase IncreasedAlcohol AbuseAnaemiaAntiretroviral TherapyAntiviral ProphylaxisAntiviral TreatmentAnxietyAnxiety DisorderArteriosclerosisArthropathyAsthmaAttention Deficit/hyperactivity DisorderAcute Hepatitis C

Showing 15 of 162 indications

Velpatasvir brand names and reporting trend

Velpatasvir is sold under the brand name Epclusa.

Brand names

Epclusa1,795

Quarterly reports (20152025)

2016202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking velpatasvir with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.