OpenClaim

Velmanase Side Effects

The most commonly reported side effects of velmanase include pyrexia, product complaint, and product dose omission issue, based on 65 FDA adverse event reports from 2011 to 2025.

Velmanase side effects

Percentages show how often each reaction appears relative to total reports for velmanase.

1
Pyrexia7.7%5
2
Product Complaint7.7%5
3
Product Dose Omission Issue7.7%5
4
Abdominal Pain6.2%4
5
Product Administration Interrupted6.2%4
6
Vomiting6.2%4
7
Pulmonary Embolism4.6%3
8
Infection4.6%3
9
Asthenia4.6%3
10
Haemoglobin Decreased4.6%3
11
Off Label Use4.6%3
12
Weight Increased4.6%3
13
Infusion Related Reaction4.6%3
14
Arthropathy4.6%3
15
Embolism Arterial3.1%2

These are voluntary reports and do not establish that velmanase caused these reactions.

Report severity

67.7%Serious44 reports
38.5%Hospitalizations25 reports
6.2%Fatal4 reports

Seriousness is determined by the reporter, not by OpenClaim.

Velmanase drug interactions

Other drugs that appear in adverse event reports alongside velmanase. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Lenalidomide6.2%4
2
Bevacizumab4.6%3
3
Fludarabine-phosphate3.1%2
4
Busulfan3.1%2
5
Thiotepa3.1%2
6
Cyclosporine3.1%2
7
Oxaliplatin1.5%1
8
Fluorouracil1.5%1
9
Azacitidine1.5%1
10
Atezolizumab1.5%1
11
Olaratumab1.5%1
12
L-glutamine1.5%1
13
Pomalidomide1.5%1

Taken alongside

1
Ondansetron13.8%9
2
Acetaminophen12.3%8
3
Prochlorperazine10.8%7
4
Lorazepam7.7%5
5
Diphenhydramine7.7%5
6
Megestrol-acetate6.2%4
7
Hydrocodone6.2%4
8
Zolpidem-tartrate6.2%4
9
Oxycodone6.2%4
10
Ergocalciferol6.2%4
11
Dexamethasone6.2%4
12
Ibuprofen4.6%3
13
Omeprazole4.6%3
14
Cetirizine-hydrochloride4.6%3
15
Albuterol4.6%3

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports velmanase side effects

44.6% of velmanase adverse event reports involve female patients and 49.2% involve male patients. The largest age group is adult at 50%. These figures reflect who reports side effects, not underlying risk.

Sex

Female44.6%
Male49.2%
Unknown6.2%

Age group

< 23.7%
2–1124.1%
12–1716.7%
18–6450.0%
65+5.6%

What is velmanase used for

Conditions and purposes for which patients were taking velmanase when the adverse event was reported.

Alpha-mannosidosisProduct Used For Unknown IndicationProduct Used For Unknown Indication

Velmanase brand names and reporting trend

Velmanase is sold under the brand name Lamzede.

Brand names

Lamzede18

Quarterly reports (20112025)

201120242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking velmanase with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.