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Vandetanib Side Effects

The most commonly reported side effects of vandetanib include diarrhoea, fatigue, and rash, based on 1,769 FDA adverse event reports from 2007 to 2025.

Vandetanib side effects

Percentages show how often each reaction appears relative to total reports for vandetanib.

1
Diarrhoea14.7%260
2
Fatigue7.7%136
3
Rash7.3%130
4
Electrocardiogram Qt Prolonged6.0%107
5
Hypertension5.5%98
6
Nausea4.2%75
7
Acne4.0%71
8
Disease Progression3.9%69
9
Diarrhoea3.6%63
10
Asthenia3.6%63
11
Headache3.4%61
12
Off Label Use3.1%55
13
Blood Pressure Increased3.1%54
14
Dyspnoea3.0%53
15
Malignant Neoplasm Progression3.0%53

These are voluntary reports and do not establish that vandetanib caused these reactions.

Report severity

67.9%Serious1,202 reports
29.9%Hospitalizations529 reports
9.3%Fatal165 reports

Seriousness is determined by the reporter, not by OpenClaim.

Vandetanib drug interactions

Other drugs that appear in adverse event reports alongside vandetanib. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Paclitaxel3.6%64
2
Gemcitabine3.6%63
3
Everolimus3.5%62
4
Carboplatin2.1%38
5
Sunitinib-malate2.1%37
6
Dexamethasone2.0%35
7
Temozolomide1.9%34
8
Pemetrexed1.7%30
9
Topotecan-hydrochloride1.5%26
10
Cabozantinib1.4%25
11
Cyclophosphamide1.3%23
12
Ranitidine1.3%23
13
Lansoprazole1.2%22
14
Docetaxel1.2%21
15
Mesna1.2%21

Taken alongside

1
Levothyroxine-sodium17.6%311
2
Acetaminophen6.1%108
3
Loperamide-hydrochloride6.0%106
4
Calcium5.4%96
5
Dexamethasone4.4%77
6
Amlodipine4.0%70
7
Oxycodone3.8%67
8
Calcitriol3.4%61
9
Omeprazole2.7%47
10
Hydrocodone2.5%45
11
Aspirin2.5%44
12
Lisinopril2.4%42
13
Metformin2.3%41
14
Ergocalciferol2.3%41
15
Pantoprazole-sodium2.0%36

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports vandetanib side effects

40.8% of vandetanib adverse event reports involve female patients and 45.4% involve male patients. The largest age group is adult at 60%. These figures reflect who reports side effects, not underlying risk.

Sex

Female40.8%
Male45.4%
Unknown13.8%

Age group

< 2<0.1%
2–113.0%
12–170.6%
18–6459.8%
65+36.5%

What is vandetanib used for

Conditions and purposes for which patients were taking vandetanib when the adverse event was reported.

AdenocarcinomaAdenocarcinoma Of ColonAdenocarcinoma PancreasAdvanced Breast CancerAnaplastic AstrocytomaAnaplastic OligodendrogliomaAdrenal Gland CancerBenign Neoplasm Of Thyroid GlandBile Duct CancerBiliary Cancer MetastaticBlood Thyroid Stimulating HormoneBlood Thyroid Stimulating Hormone AbnormalBone CancerBrain Stem GliomaBreast Cancer Metastatic

Showing 15 of 130 indications

Vandetanib brand names and reporting trend

Vandetanib is sold under the brand name Caprelsa.

Brand names

Caprelsa1,158

Quarterly reports (20072025)

20072010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking vandetanib with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.