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Vancomycin Side Effects

The most commonly reported side effects of vancomycin include acute kidney injury, off label use, and pyrexia, based on 74,312 FDA adverse event reports from 2004 to 2025. 9.7% of reports found the drug to be ineffective.

Vancomycin side effects

Percentages show how often each reaction appears relative to total reports for vancomycin.

1
Drug Ineffective9.7%7,208
2
Acute Kidney Injury7.6%5,681
3
Off Label Use6.2%4,600
4
Pyrexia4.6%3,432
5
Drug Reaction With Eosinophilia And Systemic Symptoms4.2%3,096
6
Drug Hypersensitivity3.2%2,396
7
Diarrhoea2.9%2,124
8
Rash2.8%2,096
9
Condition Aggravated2.7%1,979
10
Sepsis2.6%1,941
11
Pneumonia2.5%1,886
12
Hypotension2.3%1,688
13
Renal Failure2.3%1,676
14
Septic Shock2.1%1,595
15
Dyspnoea2.1%1,577

These are voluntary reports and do not establish that vancomycin caused these reactions.

Report severity

90.5%Serious67,225 reports
50.9%Hospitalizations37,809 reports
19.6%Fatal14,570 reports

Seriousness is determined by the reporter, not by OpenClaim.

Vancomycin drug interactions

Other drugs that appear in adverse event reports alongside vancomycin. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Meropenem7.0%5,231
2
Ceftriaxone-sodium5.1%3,809
3
Metronidazole4.8%3,569
4
Piperacillin3.9%2,905
5
Ciprofloxacin3.6%2,644
6
Cefepime-hydrochloride3.5%2,596
7
Tazobactam-sodium3.3%2,435
8
Daptomycin3.2%2,365
9
Dexamethasone3.1%2,308
10
Linezolid3.0%2,222
11
Amphotericin-b2.8%2,074
12
Gentamicin-sulfate2.7%2,043
13
Prednisone2.7%2,033
14
Methylprednisolone2.6%1,932
15
Fluconazole2.5%1,882

Taken alongside

1
Acetaminophen12.5%9,319
2
Furosemide9.3%6,874
3
Meropenem8.5%6,316
4
Ondansetron6.8%5,079
5
Cefepime-hydrochloride6.8%5,026
6
Pantoprazole-sodium6.3%4,706
7
Piperacillin6.2%4,605
8
Acyclovir6.2%4,586
9
Metronidazole6.1%4,563
10
Ceftriaxone-sodium6.0%4,423
11
Aspirin5.9%4,361
12
Insulin5.5%4,115
13
Prednisone5.5%4,084
14
Fluconazole5.4%4,030
15
Heparin5.4%3,989

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports vancomycin side effects

41.0% of vancomycin adverse event reports involve female patients and 47.5% involve male patients. The largest age group is adult at 53%. These figures reflect who reports side effects, not underlying risk.

Sex

Female41.0%
Male47.5%
Unknown11.5%

Age group

< 24.2%
2–115.4%
12–173.7%
18–6452.9%
65+33.8%

What is vancomycin used for

Conditions and purposes for which patients were taking vancomycin when the adverse event was reported.

Abdominal AbscessAbdominal Compartment SyndromeAbdominal DiscomfortAbdominal InfectionAbdominal InjuryAbdominal PainAbdominal Pain UpperAbdominal SepsisAbdominal Wall AbscessAbdominal Wound DehiscenceAbscessAbscess LimbAbscess ManagementAbscess NeckAbscess Oral

Showing 15 of 2,461 indications

Vancomycin brand names and reporting trend

Vancomycin is sold under brand names including Vancomycin, Vancomycin Hydrochloride In Plastic Container.

Brand names

Vancomycin89,548
Vancomycin Hydrochloride In Plastic Container124

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking vancomycin with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.