OpenClaim

Valdecoxib Side Effects

The most commonly reported side effects of valdecoxib include myocardial infarction, cerebrovascular accident, and stevens-johnson syndrome, based on 13,292 FDA adverse event reports from 2004 to 2025. 3.8% of reports found the drug to be ineffective.

Valdecoxib side effects

Percentages show how often each reaction appears relative to total reports for valdecoxib.

1
Myocardial Infarction27.3%3,631
2
Cerebrovascular Accident18.2%2,414
3
Stevens-johnson Syndrome10.8%1,435
4
Cardiovascular Disorder5.7%763
5
Depression5.7%758
6
Thrombosis4.3%572
7
Anxiety4.1%547
8
Chest Pain3.9%523
9
Drug Ineffective3.8%502
10
Hypertension3.6%476
11
Pain3.5%465
12
Pulmonary Embolism3.1%406
13
Dyspnoea2.9%386
14
Rash2.9%379
15
Injury2.7%356

These are voluntary reports and do not establish that valdecoxib caused these reactions.

Report severity

90.7%Serious12,060 reports
43.1%Hospitalizations5,734 reports
10.7%Fatal1,424 reports

Seriousness is determined by the reporter, not by OpenClaim.

Valdecoxib drug interactions

Other drugs that appear in adverse event reports alongside valdecoxib. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Celecoxib18.3%2,434
2
Rofecoxib16.5%2,190
3
Infliximab1.0%128
4
Ibuprofen0.9%118
5
Gabapentin0.8%108
6
Teriparatide0.8%101
7
Acetaminophen0.7%96
8
Atorvastatin-calcium0.6%86
9
Esomeprazole0.6%83
10
Alendronate-sodium0.5%72
11
Quetiapine-fumarate0.5%72
12
Oxycodone0.5%68
13
Aspirin0.5%65
14
Ethinyl-estradiol0.5%63
15
Naproxen0.5%61

Taken alongside

1
Acetaminophen7.2%956
2
Aspirin5.4%717
3
Hydrochlorothiazide4.5%595
4
Hydrocodone3.8%504
5
Levothyroxine-sodium3.7%497
6
Atorvastatin-calcium3.6%474
7
Furosemide3.2%421
8
Metoprolol2.9%391
9
Amlodipine2.7%354
10
Gabapentin2.6%344
11
Ibuprofen2.6%342
12
Celecoxib2.6%342
13
Omeprazole2.5%327
14
Lisinopril2.4%318
15
Simvastatin2.4%314

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports valdecoxib side effects

57.8% of valdecoxib adverse event reports involve female patients and 37.2% involve male patients. The largest age group is adult at 62%. These figures reflect who reports side effects, not underlying risk.

Sex

Female57.8%
Male37.2%
Unknown5.0%

Age group

< 2<0.1%
2–110.0%
12–170.3%
18–6461.9%
65+37.8%

What is valdecoxib used for

Conditions and purposes for which patients were taking valdecoxib when the adverse event was reported.

AbasiaAbdominal DiscomfortAbdominal PainAbdominal Pain LowerAccidentAccident At WorkAcetabulum FractureAnaesthesiaAnalgesiaAnalgesic Drug Level TherapeuticAnalgesic EffectAnalgesic Intervention Supportive TherapyAnalgesic TherapyAnkle FractureAnkle Operation

Showing 15 of 326 indications

Valdecoxib brand names and reporting trend

Valdecoxib is sold under the brand name Bextra.

Brand names

Bextra332

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking valdecoxib with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.