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Vadadustat Side Effects

The most commonly reported side effects of vadadustat include death, marasmus, and cardiac failure, based on 239 FDA adverse event reports from 2008 to 2025.

Vadadustat side effects

Percentages show how often each reaction appears relative to total reports for vadadustat.

1
Death6.3%15
2
Marasmus5.9%14
3
Cardiac Failure5.4%13
4
Haemoglobin Decreased5.4%13
5
Drug Interaction5.0%12
6
Pneumonia4.6%11
7
Diarrhoea4.6%11
8
Off Label Use4.2%10
9
Cardiac Failure Congestive3.8%9
10
Nausea3.8%9
11
Rhabdomyolysis3.8%9
12
Haemoglobin Increased3.3%8
13
Pneumonia Aspiration3.3%8
14
Cerebral Infarction2.9%7
15
Hypertension2.9%7

These are voluntary reports and do not establish that vadadustat caused these reactions.

Report severity

99.6%Serious238 reports
39.7%Hospitalizations95 reports
38.9%Fatal93 reports

Seriousness is determined by the reporter, not by OpenClaim.

Vadadustat drug interactions

Other drugs that appear in adverse event reports alongside vadadustat. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Daprodustat7.5%18
2
Valsartan2.9%7
3
Sacubitril2.5%6
4
Rosuvastatin2.5%6
5
Sodium-zirconium-cyclosilicate1.7%4
6
Amlodipine1.3%3
7
Etelcalcetide0.8%2
8
Bisoprolol-fumarate0.8%2
9
Darbepoetin-alfa0.8%2
10
Canagliflozin0.8%2
11
Dapagliflozin0.8%2
12
Avacopan0.8%2
13
Edoxaban0.8%2
14
Clopidogrel-bisulfate0.8%2
15
Epoetin0.8%2

Taken alongside

1
Darbepoetin-alfa18.8%45
2
Amlodipine18.4%44
3
Febuxostat13.0%31
4
Methoxy-polyethylene-glycol-epoetin-beta12.6%30
5
Ferrous-fumarate11.7%28
6
Aspirin9.6%23
7
Carvedilol9.2%22
8
Nifedipine9.2%22
9
Furosemide8.8%21
10
Lansoprazole8.8%21
11
Ferric-citrate7.5%18
12
Vonoprazan-fumarate7.1%17
13
Lanthanum-carbonate6.7%16
14
Bisoprolol-fumarate6.7%16
15
Olmesartan-medoxomil6.7%16

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports vadadustat side effects

32.6% of vadadustat adverse event reports involve female patients and 48.5% involve male patients. The largest age group is elderly at 81%. These figures reflect who reports side effects, not underlying risk.

Sex

Female32.6%
Male48.5%
Unknown18.8%

Age group

< 20.0%
2–110.0%
12–170.0%
18–6418.8%
65+81.2%

What is vadadustat used for

Conditions and purposes for which patients were taking vadadustat when the adverse event was reported.

AnaemiaBladder CancerChronic Kidney DiseaseDyslipidaemiaEmphysemaHaemoglobin DecreasedNephrogenic AnaemiaNephrogenic AnaemiaProduct Used For Unknown IndicationProduct Used For Unknown IndicationPulmonary Fibrosis

Vadadustat brand names and reporting trend

Vadadustat is sold under the brand name Vafseo.

Brand names

Vafseo373

Quarterly reports (20082025)

20082025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking vadadustat with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.