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Urokinase Side Effects

The most commonly reported side effects of urokinase include off label use, anaemia, and drug interaction, based on 342 FDA adverse event reports from 2004 to 2025. 7.6% of reports found the drug to be ineffective.

Urokinase side effects

Percentages show how often each reaction appears relative to total reports for urokinase.

1
Drug Ineffective7.6%26
2
Off Label Use4.7%16
3
Anaemia4.4%15
4
Drug Interaction4.1%14
5
Pleural Effusion4.1%14
6
Death3.8%13
7
Haematuria3.5%12
8
Diarrhoea3.5%12
9
Hypotension3.5%12
10
Pneumonia3.2%11
11
Myositis2.9%10
12
Haematoma2.9%10
13
Gastrointestinal Haemorrhage2.9%10
14
Sepsis2.9%10
15
Abdominal Pain2.9%10

These are voluntary reports and do not establish that urokinase caused these reactions.

Report severity

98.2%Serious336 reports
45.6%Hospitalizations156 reports
22.8%Fatal78 reports

Seriousness is determined by the reporter, not by OpenClaim.

Urokinase drug interactions

Other drugs that appear in adverse event reports alongside urokinase. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Heparin14.0%48
2
Alteplase9.4%32
3
Cyclophosphamide6.7%23
4
Prednisolone6.4%22
5
Aspirin5.6%19
6
Doxorubicin-hydrochloride5.3%18
7
Enoxaparin-sodium3.8%13
8
Rivaroxaban3.8%13
9
Warfarin3.5%12
10
Amphotericin-b3.2%11
11
Apomorphine-hydrochloride2.9%10
12
Meropenem2.9%10
13
Rituximab2.9%10
14
Methylprednisolone2.6%9
15
Gemfibrozil2.6%9

Taken alongside

1
Heparin21.3%73
2
Furosemide17.5%60
3
Acetaminophen15.5%53
4
Dexamethasone12.0%41
5
Omeprazole9.6%33
6
Aspirin9.4%32
7
Vancomycin8.5%29
8
Warfarin8.5%29
9
Potassium-chloride8.5%29
10
Sodium-chloride8.2%28
11
Meropenem7.6%26
12
Sulfamethoxazole7.6%26
13
Insulin7.0%24
14
Hydrocortisone6.7%23
15
Methylprednisolone6.7%23

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports urokinase side effects

35.1% of urokinase adverse event reports involve female patients and 50.9% involve male patients. The largest age group is adult at 50%. These figures reflect who reports side effects, not underlying risk.

Sex

Female35.1%
Male50.9%
Unknown14.0%

Age group

< 23.0%
2–114.9%
12–173.7%
18–6450.0%
65+38.4%

What is urokinase used for

Conditions and purposes for which patients were taking urokinase when the adverse event was reported.

Acute Myocardial InfarctionAcute Promyelocytic LeukaemiaAngioplastyAnticoagulant TherapyArterial ThrombosisArterial ThrombosisCarotid Artery OcclusionCatheter ManagementCatheter Related ComplicationCerebral Artery OcclusionCerebral InfarctionCerebral Venous ThrombosisCirculatory CollapseCardiac Failure AcuteCardiovascular Disorder

Showing 15 of 70 indications

Urokinase brand names and reporting trend

Urokinase is sold under the brand name Kinlytic.

Brand names

Kinlytic373

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking urokinase with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.