OpenClaim

Ulipristal Side Effects

The most commonly reported side effects of ulipristal include pain, injury, and emotional distress, based on 9,337 FDA adverse event reports from 2004 to 2025. 3.6% of reports found the drug to be ineffective.

Ulipristal side effects

Percentages show how often each reaction appears relative to total reports for ulipristal.

1
Pain28.2%2,632
2
Injury28.2%2,630
3
Emotional Distress17.8%1,664
4
Deep Vein Thrombosis14.6%1,361
5
Anxiety14.5%1,356
6
Pulmonary Embolism13.4%1,255
7
General Physical Health Deterioration11.0%1,027
8
Cholecystitis Chronic5.3%496
9
Anhedonia5.2%487
10
Thrombosis5.0%465
11
Abdominal Pain4.7%437
12
Cerebrovascular Accident4.6%427
13
Gallbladder Disorder3.8%359
14
Breast Cancer Female3.7%347
15
Nausea3.7%346

These are voluntary reports and do not establish that ulipristal caused these reactions.

Report severity

82.3%Serious7,687 reports
36.4%Hospitalizations3,396 reports
2.6%Fatal240 reports

Seriousness is determined by the reporter, not by OpenClaim.

Ulipristal drug interactions

Other drugs that appear in adverse event reports alongside ulipristal. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Ethinyl-estradiol42.7%3,984
2
Drospirenone42.4%3,956
3
Medroxyprogesterone-acetate5.3%496
4
Adalimumab3.5%327
5
Estrogens3.4%317
6
Sodium-oxybate1.8%168
7
Methotrexate1.7%161
8
Levomefolate-calcium1.5%140
9
Etanercept1.2%116
10
Infliximab1.2%109
11
Hydroxychloroquine-sulfate1.1%104
12
Rituximab1.1%101
13
Leflunomide1.0%95
14
Carbamazepine0.9%82
15
Sulfasalazine0.9%82

Taken alongside

1
Acetaminophen13.9%1,294
2
Ibuprofen10.0%931
3
Albuterol6.5%606
4
Hydrocodone6.5%606
5
Ergocalciferol6.2%578
6
Levothyroxine-sodium6.1%568
7
Omeprazole5.4%503
8
Aspirin4.7%443
9
Oxycodone4.7%438
10
Fluticasone4.6%434
11
Prednisone4.6%428
12
Alprazolam4.0%370
13
Naproxen3.9%362
14
Ondansetron3.9%361
15
Promethazine-hydrochloride3.4%322

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports ulipristal side effects

86.6% of ulipristal adverse event reports involve female patients and 9.6% involve male patients. The largest age group is adult at 81%. These figures reflect who reports side effects, not underlying risk.

Sex

Female86.6%
Male9.6%
Unknown3.8%

Age group

< 22.5%
2–112.2%
12–173.7%
18–6481.0%
65+10.6%

What is ulipristal used for

Conditions and purposes for which patients were taking ulipristal when the adverse event was reported.

Abdominal DiscomfortAbdominal DistensionAbdominal PainAbdominal Pain LowerAbdominal Pain UpperAbortion InducedAccidental ExposureAcneAcne CysticAcrochordon ExcisionAdenomyosisAdnexa Uteri PainAlopeciaAmenorrhoeaAnaemia

Showing 15 of 323 indications

Ulipristal brand names and reporting trend

Ulipristal is sold under the brand name Ella.

Brand names

Ella248

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking ulipristal with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.