OpenClaim

Ubrogepant Side Effects

The most commonly reported side effects of ubrogepant include migraine, nausea, and headache, based on 5,331 FDA adverse event reports from 2017 to 2025. 18.4% of reports found the drug to be ineffective.

Ubrogepant side effects

Percentages show how often each reaction appears relative to total reports for ubrogepant.

1
Drug Ineffective18.4%981
2
Migraine14.3%761
3
Nausea9.3%497
4
Headache8.9%476
5
Fatigue6.1%326
6
Dizziness4.9%262
7
Off Label Use4.7%252
8
Pain4.3%227
9
Vomiting3.6%192
10
Product Dose Omission Issue3.6%192
11
Pruritus2.8%150
12
Somnolence2.8%149
13
Covid-192.7%146
14
Injection Site Pain2.7%145
15
Feeling Abnormal2.6%140

These are voluntary reports and do not establish that ubrogepant caused these reactions.

Report severity

32.7%Serious1,743 reports
9.9%Hospitalizations530 reports
1.5%Fatal78 reports

Seriousness is determined by the reporter, not by OpenClaim.

Ubrogepant drug interactions

Other drugs that appear in adverse event reports alongside ubrogepant. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Eptinezumab-jjmr5.7%305
2
Galcanezumab-gnlm5.6%296
3
Atogepant4.6%244
4
Dupilumab4.3%230
5
Rimegepant4.2%225
6
Erenumab-aooe4.1%219
7
Sodium-oxybate3.8%202
8
Onabotulinumtoxina3.6%191
9
Fremanezumab-vfrm2.2%115
10
Calcium-oxybate1.8%98
11
Magnesium-oxybate1.8%98
12
Potassium-oxybate1.8%98
13
Sumatriptan1.1%57
14
Treprostinil0.9%46
15
Acetaminophen0.8%45

Taken alongside

1
Ergocalciferol11.3%605
2
Acetaminophen11.3%600
3
Ondansetron10.1%537
4
Albuterol9.9%529
5
Gabapentin9.2%488
6
Topiramate8.1%432
7
Fluticasone7.4%394
8
Omeprazole7.0%375
9
Levothyroxine-sodium7.0%372
10
Montelukast-sodium6.2%331
11
Aspirin6.0%322
12
Pantoprazole-sodium5.7%302
13
Onabotulinumtoxina5.6%301
14
Duloxetine-hydrochloride5.6%297
15
Famotidine5.3%281

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports ubrogepant side effects

72.2% of ubrogepant adverse event reports involve female patients and 11.1% involve male patients. The largest age group is adult at 81%. These figures reflect who reports side effects, not underlying risk.

Sex

Female72.2%
Male11.1%
Unknown16.7%

Age group

< 20.1%
2–110.0%
12–171.7%
18–6480.9%
65+17.2%

What is ubrogepant used for

Conditions and purposes for which patients were taking ubrogepant when the adverse event was reported.

AuraCluster HeadacheCentral Pain SyndromeCluster HeadacheDizzinessDrug TherapyEpilepsyHeadacheHemiplegic MigraineHallucination, AuditoryHeadacheHemiplegic MigraineHypogammaglobulinaemiaMigraineMigraine Prophylaxis

Showing 15 of 40 indications

Ubrogepant brand names and reporting trend

Ubrogepant is sold under the brand name Ubrelvy.

Brand names

Ubrelvy221

Quarterly reports (20172025)

20182020202220242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking ubrogepant with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.