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Tucatinib Side Effects

The most commonly reported side effects of tucatinib include diarrhoea, nausea, and fatigue, based on 6,532 FDA adverse event reports from 2018 to 2025.

Tucatinib side effects

Percentages show how often each reaction appears relative to total reports for tucatinib.

1
Diarrhoea25.3%1,653
2
Nausea13.5%885
3
Fatigue13.5%883
4
Vomiting7.7%501
5
Off Label Use7.0%455
6
Death6.7%436
7
Malignant Neoplasm Progression5.8%382
8
Palmar-plantar Erythrodysaesthesia Syndrome5.7%374
9
Product Dose Omission Issue5.2%342
10
Asthenia5.2%340
11
Decreased Appetite4.5%296
12
Disease Progression4.5%296
13
Metastases To Central Nervous System4.4%288
14
Dehydration3.9%252
15
Neoplasm Progression3.8%251

These are voluntary reports and do not establish that tucatinib caused these reactions.

Report severity

65.3%Serious4,265 reports
27.9%Hospitalizations1,821 reports
10.5%Fatal687 reports

Seriousness is determined by the reporter, not by OpenClaim.

Tucatinib drug interactions

Other drugs that appear in adverse event reports alongside tucatinib. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Capecitabine50.6%3,302
2
Trastuzumab41.7%2,727
3
Pertuzumab6.7%440
4
Docetaxel3.3%215
5
Loperamide-hydrochloride3.0%197
6
Denosumab2.4%155
7
Paclitaxel2.0%129
8
Lapatinib-ditosylate1.9%121
9
Oxaliplatin1.7%113
10
Fluorouracil1.7%108
11
Vinorelbine-tartrate1.4%92
12
Letrozole1.4%89
13
Doxorubicin-hydrochloride1.4%89
14
Fulvestrant1.2%76
15
Levetiracetam0.9%60

Taken alongside

1
Capecitabine8.7%566
2
Trastuzumab8.6%563
3
Ondansetron7.1%462
4
Dexamethasone5.3%345
5
Acetaminophen4.7%310
6
Pantoprazole-sodium4.5%291
7
Loperamide-hydrochloride4.2%272
8
Omeprazole3.0%194
9
Levetiracetam2.9%188
10
Alprazolam2.8%182
11
Levothyroxine-sodium2.7%176
12
Lorazepam2.3%147
13
Denosumab2.3%147
14
Hydromorphone-hydrochloride2.2%146
15
Furosemide2.2%143

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports tucatinib side effects

86.7% of tucatinib adverse event reports involve female patients and 4.8% involve male patients. The largest age group is adult at 67%. These figures reflect who reports side effects, not underlying risk.

Sex

Female86.7%
Male4.8%
Unknown8.6%

Age group

< 20.2%
2–110.0%
12–170.0%
18–6467.2%
65+32.7%

What is tucatinib used for

Conditions and purposes for which patients were taking tucatinib when the adverse event was reported.

AdenocarcinomaAdenocarcinoma GastricAdenocarcinoma Of AppendixAdenocarcinoma Of ColonAdenocarcinoma Of Salivary GlandBenign Breast NeoplasmBladder CancerBone CancerBone Marrow DisorderBrain Cancer MetastaticBrain NeoplasmBrain Neoplasm MalignantBreast CancerBreast Cancer FemaleBreast Cancer Male

Showing 15 of 159 indications

Tucatinib brand names and reporting trend

Tucatinib is sold under the brand name Tukysa.

Brand names

Tukysa3,407

Quarterly reports (20182025)

2018202220242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking tucatinib with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.