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Trypan Side Effects

The most commonly reported side effects of trypan include toxic anterior segment syndrome, blindness, and corneal oedema, based on 50 FDA adverse event reports from 2010 to 2025.

Trypan side effects

Percentages show how often each reaction appears relative to total reports for trypan.

1
Toxic Anterior Segment Syndrome46.0%23
2
Blindness44.0%22
3
Corneal Oedema20.0%10
4
Product Quality Issue12.0%6
5
Cerebral Infarction6.0%3
6
Thyroid Disorder6.0%3
7
Pigmentation Disorder6.0%3
8
Condition Aggravated4.0%2
9
Vision Blurred4.0%2
10
Endophthalmitis4.0%2
11
Off Label Use4.0%2
12
Endophthalmitis2.0%1
13
Off Label Use2.0%1
14
Toxic Anterior Segment Syndrome2.0%1
15
Eye Oedema2.0%1

These are voluntary reports and do not establish that trypan caused these reactions.

Report severity

92.0%Serious46 reports
4.0%Hospitalizations2 reports
4.0%Fatal2 reports

Seriousness is determined by the reporter, not by OpenClaim.

Trypan drug interactions

Other drugs that appear in adverse event reports alongside trypan. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Minocycline-hydrochloride6.0%3
2
Phenylephrine4.0%2
3
Brilliant-blue-g4.0%2
4
Latanoprost4.0%2
5
Epinephrine2.0%1
6
Zoledronic-acid2.0%1
7
Proparacaine-hydrochloride2.0%1
8
Dexamethasone2.0%1
9
Thiopental-sodium2.0%1
10
Dexmedetomidine-hydrochloride2.0%1
11
Morphine-sulfate2.0%1
12
Clobazam2.0%1
13
Midazolam2.0%1
14
Pimavanserin2.0%1

Taken alongside

1
Lidocaine42.0%21
2
Tropicamide40.0%20
3
Prednisolone12.0%6
4
Moxifloxacin-hydrochloride6.0%3
5
Calcium-chloride4.0%2
6
Potassium-chloride4.0%2
7
Sodium-chloride4.0%2
8
Nepafenac4.0%2
9
Magnesium-chloride2.0%1
10
Sodium-acetate2.0%1
11
Sodium-citrate2.0%1
12
Apraclonidine-hydrochloride2.0%1
13
Timolol2.0%1
14
Estrogens2.0%1
15
Diphenhydramine2.0%1

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports trypan side effects

34.0% of trypan adverse event reports involve female patients and 54.0% involve male patients. The largest age group is elderly at 60%. These figures reflect who reports side effects, not underlying risk.

Sex

Female34.0%
Male54.0%
Unknown12.0%

Age group

< 20.0%
2–112.5%
12–172.5%
18–6435.0%
65+60.0%

What is trypan used for

Conditions and purposes for which patients were taking trypan when the adverse event was reported.

CataractCataract OperationComputerised TomogramDiagnostic ProcedureEye DisorderLens ExtractionOphthalmological ExaminationPhotodynamic Diagnostic ProcedureProduct Used For Unknown IndicationReaction To Azo-dyesVital Dye Staining Cornea PresentVitrectomy

Trypan brand names and reporting trend

Trypan is sold under the brand name Membraneblue.

Brand names

Membraneblue33

Quarterly reports (20102025)

20102025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking trypan with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.