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Trospium Side Effects

The most commonly reported side effects of trospium include nausea, vomiting, and fall, based on 6,668 FDA adverse event reports from 2004 to 2025. 4.7% of reports found the drug to be ineffective.

Trospium side effects

Percentages show how often each reaction appears relative to total reports for trospium.

1
Nausea7.3%485
2
Vomiting5.5%365
3
Fall4.8%322
4
Drug Ineffective4.7%314
5
Fatigue4.6%307
6
Dizziness4.2%280
7
Urinary Tract Infection4.1%272
8
Constipation4.1%271
9
Off Label Use3.8%256
10
Diarrhoea3.1%207
11
Asthenia3.0%198
12
Headache2.8%187
13
Dyspnoea2.6%175
14
Gait Disturbance2.6%174
15
Urinary Retention2.5%164

These are voluntary reports and do not establish that trospium caused these reactions.

Report severity

53.9%Serious3,595 reports
29.9%Hospitalizations1,992 reports
5.2%Fatal348 reports

Seriousness is determined by the reporter, not by OpenClaim.

Trospium drug interactions

Other drugs that appear in adverse event reports alongside trospium. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Xanomeline-tartrate21.1%1,408
2
Dalfampridine4.5%303
3
Pantoprazole-sodium2.2%147
4
Levodopa2.1%139
5
Dimethyl1.9%127
6
Adalimumab1.8%121
7
Aspirin1.7%114
8
Omeprazole1.7%113
9
Carbidopa1.7%113
10
Lenalidomide1.7%111
11
Pimavanserin1.7%111
12
Interferon1.6%110
13
Pregabalin1.5%102
14
Sodium-oxybate1.5%98
15
Ocrelizumab1.3%87

Taken alongside

1
Ergocalciferol12.9%862
2
Aspirin12.1%810
3
Levothyroxine-sodium12.1%805
4
Acetaminophen11.9%791
5
Gabapentin10.3%689
6
Atorvastatin-calcium10.2%682
7
Omeprazole9.8%651
8
Pantoprazole-sodium8.0%531
9
Amlodipine7.2%478
10
Metoprolol7.1%473
11
Baclofen7.0%465
12
Albuterol6.9%463
13
Lisinopril6.8%451
14
Simvastatin6.6%437
15
Tamsulosin-hydrochloride6.5%436

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports trospium side effects

54.4% of trospium adverse event reports involve female patients and 34.9% involve male patients. The largest age group is elderly at 54%. These figures reflect who reports side effects, not underlying risk.

Sex

Female54.4%
Male34.9%
Unknown10.8%

Age group

< 2<0.1%
2–110.4%
12–170.5%
18–6445.3%
65+53.7%

What is trospium used for

Conditions and purposes for which patients were taking trospium when the adverse event was reported.

Abdominal PainAbdominal RigidityAccidental ExposureAffective DisorderArthritisAutomatic BladderAbdominal PainAffective DisorderAggressionAnticholinergic SyndromeAnxietyAutism Spectrum DisorderBenign Prostatic HyperplasiaBladder Catheter TemporaryBladder Discomfort

Showing 15 of 162 indications

Trospium brand names and reporting trend

Trospium is sold under the brand name Sanctura Xr.

Brand names

Sanctura Xr4,269

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking trospium with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.