OpenClaim

Troglitazone Side Effects

The most commonly reported side effects of troglitazone include bladder cancer, cardiac failure congestive, and myocardial infarction, based on 222 FDA adverse event reports from 2004 to 2025.

#1 Reported: Bladder CancerAll side effects ↓Top Co-Medication: Pioglitazone-hydrochlorideDrug interactions ↓71% of Reports Are AdultDemographics ↓

Troglitazone side effects

Percentages show how often each reaction appears relative to total reports for troglitazone.

1
Bladder Cancer18.0%40
2
Cardiac Failure Congestive13.1%29
3
Myocardial Infarction11.3%25
4
Renal Failure7.2%16
5
Blood Glucose Increased6.3%14
6
Diarrhoea6.3%14
7
Renal Failure Acute6.3%14
8
Cardiac Disorder5.9%13
9
Fatigue5.9%13
10
Death5.9%13
11
Chronic Kidney Disease5.9%13
12
Cerebrovascular Accident5.4%12
13
Diabetes Mellitus5.4%12
14
Renal Failure5.4%12
15
Diabetes Mellitus Inadequate Control5.0%11

These are voluntary reports and do not establish that troglitazone caused these reactions.

Report severity

90.5%Serious201 reports
44.6%Hospitalizations99 reports
27.9%Fatal62 reports

Seriousness is determined by the reporter, not by OpenClaim.

Troglitazone drug interactions

Other drugs that appear in adverse event reports alongside troglitazone. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Pioglitazone-hydrochloride24.8%55
2
Rosiglitazone-maleate18.0%40
3
Metformin7.7%17
4
Insulin7.2%16
5
Lansoprazole6.8%15
6
Omeprazole6.8%15
7
Esomeprazole5.9%13
8
Pantoprazole-sodium4.5%10
9
Rofecoxib4.1%9
10
Glipizide4.1%9
11
Lisinopril2.7%6
12
Hydrochlorothiazide2.3%5
13
Somatropin2.3%5
14
Exenatide-synthetic1.8%4
15
Digoxin1.8%4

Taken alongside

1
Metformin48.6%108
2
Insulin46.4%103
3
Rosiglitazone-maleate21.6%48
4
Glipizide19.8%44
5
Atorvastatin-calcium16.7%37
6
Glyburide16.7%37
7
Furosemide16.7%37
8
Aspirin16.2%36
9
Lisinopril14.9%33
10
Acetaminophen14.4%32
11
Glimepiride13.1%29
12
Levothyroxine-sodium12.2%27
13
Pioglitazone-hydrochloride11.3%25
14
Simvastatin11.3%25
15
Gabapentin10.4%23

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports troglitazone side effects

44.1% of troglitazone adverse event reports involve female patients and 31.1% involve male patients. The largest age group is adult at 71%. These figures reflect who reports side effects, not underlying risk.

Sex

Female44.1%
Male31.1%
Unknown24.8%

Age group

< 20.0%
2–110.0%
12–170.0%
18–6471.4%
65+28.6%

What is troglitazone used for

Conditions and purposes for which patients were taking troglitazone when the adverse event was reported.

Blood Glucose AbnormalDepressionDiabetes MellitusDiabetes Mellitus Insulin-dependentDiabetes Mellitus Non-insulin-dependentDrug Use For Unknown IndicationIll-defined DisorderInsulin ResistancePancreatic CarcinomaProduct Used For Unknown IndicationProduct Used For Unknown IndicationType 1 Diabetes MellitusType 2 Diabetes Mellitus

Troglitazone brand names and reporting trend

Troglitazone is sold under the brand name Prelay.

Brand names

Prelay62

Quarterly reports (2004–2025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking troglitazone with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.

Check my medications