OpenClaim

Triptorelin Side Effects

The most commonly reported side effects of triptorelin include off label use, death, and needle issue, based on 6,418 FDA adverse event reports from 2004 to 2025. 3.2% of reports found the drug to be ineffective.

Triptorelin side effects

Percentages show how often each reaction appears relative to total reports for triptorelin.

1
Off Label Use8.5%548
2
Death6.7%431
3
Needle Issue3.8%244
4
Disease Progression3.4%218
5
Drug Ineffective3.2%206
6
Fatigue3.2%205
7
Hot Flush3.2%204
8
Product Dose Omission Issue2.9%184
9
Headache2.8%177
10
Weight Increased2.7%171
11
Asthenia2.5%160
12
Inappropriate Schedule Of Product Administration2.3%147
13
Nausea2.2%140
14
Injection Site Pain2.2%138
15
Dizziness2.1%133

These are voluntary reports and do not establish that triptorelin caused these reactions.

Report severity

66.4%Serious4,260 reports
25.1%Hospitalizations1,613 reports
10.7%Fatal688 reports

Seriousness is determined by the reporter, not by OpenClaim.

Triptorelin drug interactions

Other drugs that appear in adverse event reports alongside triptorelin. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Enzalutamide4.9%317
2
Bicalutamide4.3%278
3
Letrozole3.5%227
4
Abiraterone-acetate3.5%222
5
Docetaxel2.0%127
6
Tamoxifen-citrate2.0%126
7
Apalutamide1.9%119
8
Zoledronic-acid1.8%114
9
Exemestane1.6%104
10
Megestrol-acetate1.5%99
11
Prednisone1.4%87
12
Denosumab1.2%80
13
Leuprolide1.1%69
14
Follitropin-alfa-beta0.9%59
15
Cyclophosphamide0.9%56

Taken alongside

1
Aspirin3.7%240
2
Acetaminophen3.5%223
3
Prednisone3.3%213
4
Bicalutamide3.0%191
5
Omeprazole3.0%191
6
Tamsulosin-hydrochloride2.9%184
7
Ergocalciferol2.8%182
8
Amlodipine2.6%167
9
Atorvastatin-calcium2.6%167
10
Metoprolol2.5%160
11
Metformin2.4%154
12
Denosumab2.3%149
13
Levothyroxine-sodium2.0%131
14
Calcium1.8%113
15
Hydrochlorothiazide1.7%108

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports triptorelin side effects

40.4% of triptorelin adverse event reports involve female patients and 51.0% involve male patients. The largest age group is elderly at 49%. These figures reflect who reports side effects, not underlying risk.

Sex

Female40.4%
Male51.0%
Unknown8.5%

Age group

< 20.2%
2–1119.3%
12–173.2%
18–6428.1%
65+49.2%

What is triptorelin used for

Conditions and purposes for which patients were taking triptorelin when the adverse event was reported.

Accidental Exposure To ProductAcromegalyAdenomyosisAdrenocortical Insufficiency AcuteAdrenocortical Steroid TherapyAdrenogenital SyndromeAmenorrhoeaAndrogen DeficiencyAndrogen Replacement TherapyAndrogen TherapyAngioedemaAngiomyxomaAntiandrogen TherapyAntiphospholipid AntibodiesAnxiety Disorder

Showing 15 of 262 indications

Triptorelin brand names and reporting trend

Triptorelin is sold under the brand name Trelstar.

Brand names

Trelstar4,234

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking triptorelin with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.