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Triprolidine Side Effects

The most commonly reported side effects of triprolidine include joint swelling, pemphigus, and pericarditis, based on 977 FDA adverse event reports from 2004 to 2025.

Triprolidine side effects

Percentages show how often each reaction appears relative to total reports for triprolidine.

1
Joint Swelling28.8%281
2
Pemphigus27.3%267
3
Pericarditis26.3%257
4
Oedema25.2%246
5
Type 2 Diabetes Mellitus24.8%242
6
Weight Increased24.5%239
7
Urticaria24.3%237
8
Psoriatic Arthropathy24.3%237
9
Nausea24.2%236
10
Stomatitis24.2%236
11
Pyrexia23.6%231
12
Sinusitis23.6%231
13
Rheumatoid Arthritis23.5%230
14
Injury23.0%225
15
Abdominal Discomfort22.9%224

These are voluntary reports and do not establish that triprolidine caused these reactions.

Report severity

87.8%Serious858 reports
49.3%Hospitalizations482 reports
23.3%Fatal228 reports

Seriousness is determined by the reporter, not by OpenClaim.

Triprolidine drug interactions

Other drugs that appear in adverse event reports alongside triprolidine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Pseudoephedrine57.7%564
2
Adalimumab37.4%365
3
Methotrexate35.9%351
4
Abatacept35.8%350
5
Hydroxychloroquine-sulfate35.5%347
6
Cetirizine-hydrochloride35.2%344
7
Etanercept34.6%338
8
Golimumab34.3%335
9
Leflunomide34.2%334
10
Diclofenac34.2%334
11
Tocilizumab34.1%333
12
Rituximab33.8%330
13
Acetaminophen33.6%328
14
Prednisone33.2%324
15
Sulfasalazine33.1%323

Taken alongside

1
Pseudoephedrine35.5%347
2
Acetaminophen34.1%333
3
Ergocalciferol30.0%293
4
Ibuprofen29.4%287
5
Lorazepam27.7%271
6
Pantoprazole-sodium27.4%268
7
Sulfasalazine26.6%260
8
Caffeine23.3%228
9
Lisinopril23.1%226
10
Quetiapine-fumarate22.9%224
11
Fish22.0%215
12
Lansoprazole20.8%203
13
Ramipril20.3%198
14
Cholecalciferol17.6%172
15
Calcium17.0%166

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports triprolidine side effects

68.8% of triprolidine adverse event reports involve female patients and 22.1% involve male patients. The largest age group is adult at 66%. These figures reflect who reports side effects, not underlying risk.

Sex

Female68.8%
Male22.1%
Unknown9.1%

Age group

< 20.5%
2–112.3%
12–172.8%
18–6466.2%
65+28.3%

What is triprolidine used for

Conditions and purposes for which patients were taking triprolidine when the adverse event was reported.

AnaemiaAntiallergic TherapyAntitussive TherapyAsthmaAbdominal Pain UpperAdverse EventChronic SinusitisCoughDizzinessDrug Exposure During PregnancyDrug Use For Unknown IndicationDermatitis AtopicEpistaxisExtrapyramidal DisorderFeeling Hot

Showing 15 of 67 indications

Triprolidine brand names and reporting trend

Triprolidine is sold under the brand name Triprolidine And Pseudoephedrine Hydrochlorides W/ Codeine.

Brand names

Triprolidine And Pseudoephedrine Hydrochlorides W/ Codeine2

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking triprolidine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.