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Tripelennamine Side Effects

The most commonly reported side effects of tripelennamine include headache, white blood cell count increased, and conjunctival haemorrhage, based on 16 FDA adverse event reports from 2008 to 2025.

Tripelennamine side effects

Percentages show how often each reaction appears relative to total reports for tripelennamine.

1
Headache18.8%3
2
White Blood Cell Count Increased18.8%3
3
Conjunctival Haemorrhage18.8%3
4
Drug Abuse18.8%3
5
Arthralgia18.8%3
6
Photophobia18.8%3
7
Feeling Hot18.8%3
8
Pleuritic Pain18.8%3
9
Eye Irritation18.8%3
10
Chills18.8%3
11
Eye Pain18.8%3
12
Ear Pain18.8%3
13
Peritoneal Dialysis Complication12.5%2
14
Peritonitis Bacterial12.5%2
15
Lacrimation Increased12.5%2

These are voluntary reports and do not establish that tripelennamine caused these reactions.

Report severity

93.8%Serious15 reports
50.0%Hospitalizations8 reports
25.0%Fatal4 reports

Seriousness is determined by the reporter, not by OpenClaim.

Tripelennamine drug interactions

Other drugs that appear in adverse event reports alongside tripelennamine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Pentazocine25.0%4
2
Quetiapine-fumarate12.5%2
3
Calcium-chloride12.5%2
4
Dextrose12.5%2
5
Magnesium-chloride12.5%2
6
Sodium-chloride12.5%2
7
Sodium-lactate12.5%2
8
Prednisone12.5%2
9
Ciprofloxacin12.5%2
10
Bevacizumab6.3%1
11
Rituximab6.3%1
12
Cyclophosphamide6.3%1
13
Doxorubicin-hydrochloride6.3%1
14
Vincristine-sulfate6.3%1
15
Dihydrocodeine-bitartrate6.3%1

Taken alongside

1
Rifampin12.5%2
2
Isoniazid12.5%2
3
Estropipate12.5%2
4
Amiloride-hydrochloride12.5%2
5
Calcitriol12.5%2
6
Gramicidin12.5%2
7
Neomycin-sulfate12.5%2
8
Polymyxin-b-sulfate12.5%2
9
Pyrazinamide6.3%1
10
Ethambutol-hydrochloride6.3%1
11
Sodium-chloride6.3%1
12
Vitamin-a-palmitate6.3%1
13
Heparin6.3%1
14
Pantoprazole-sodium6.3%1
15
Cromolyn-sodium6.3%1

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports tripelennamine side effects

37.5% of tripelennamine adverse event reports involve female patients and 50.0% involve male patients. The largest age group is adult at 45%. These figures reflect who reports side effects, not underlying risk.

Sex

Female37.5%
Male50.0%
Unknown12.5%

Age group

< 29.1%
2–1118.2%
12–179.1%
18–6445.5%
65+18.2%

What is tripelennamine used for

Conditions and purposes for which patients were taking tripelennamine when the adverse event was reported.

Antibiotic ProphylaxisDrug AbuseDrug Use For Unknown IndicationProduct Used For Unknown IndicationTuberculosisTuberculous Pleurisy

Tripelennamine brand names and reporting trend

Tripelennamine is sold under brand names including Pbz-sr, Pbz.

Brand names

Pbz-sr4
Pbz1

Quarterly reports (20082025)

20082025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking tripelennamine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.