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Trimipramine Side Effects

The most commonly reported side effects of trimipramine include toxicity to various agents, nausea, and drug interaction, based on 2,059 FDA adverse event reports from 2004 to 2025. 3.9% of reports found the drug to be ineffective.

Trimipramine side effects

Percentages show how often each reaction appears relative to total reports for trimipramine.

1
Toxicity To Various Agents7.1%147
2
Nausea6.2%128
3
Drug Interaction6.0%123
4
Dizziness5.6%116
5
Fatigue5.2%107
6
Vomiting5.1%105
7
Off Label Use4.9%101
8
Depression4.3%89
9
Somnolence4.2%87
10
Headache4.1%85
11
Fall4.0%83
12
Drug Ineffective3.9%80
13
Arthralgia3.6%75
14
Drug Abuse3.6%74
15
Coma3.4%71

These are voluntary reports and do not establish that trimipramine caused these reactions.

Report severity

95.3%Serious1,962 reports
53.8%Hospitalizations1,108 reports
13.7%Fatal282 reports

Seriousness is determined by the reporter, not by OpenClaim.

Trimipramine drug interactions

Other drugs that appear in adverse event reports alongside trimipramine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Lorazepam7.4%153
2
Pregabalin6.7%138
3
Ibuprofen5.9%121
4
Duloxetine-hydrochloride5.8%120
5
Quetiapine-fumarate5.3%110
6
Diazepam5.2%108
7
Sulfamethoxazole5.2%108
8
Mirtazapine5.0%103
9
Tramadol-hydrochloride5.0%103
10
Venlafaxine4.5%93
11
Aspirin4.3%89
12
Hydrochlorothiazide4.3%88
13
Citalopram-hydrobromide4.2%86
14
Adalimumab4.1%85
15
Olanzapine3.9%80

Taken alongside

1
Pantoprazole-sodium11.9%244
2
Levothyroxine-sodium8.2%168
3
Aspirin8.0%165
4
Ramipril6.6%135
5
Simvastatin5.6%115
6
Acetaminophen5.2%107
7
Bisoprolol-fumarate5.2%107
8
Metoprolol4.9%100
9
Ibuprofen4.8%99
10
Amlodipine4.7%97
11
Omeprazole4.4%91
12
Pregabalin4.3%89
13
Atorvastatin-calcium4.1%84
14
Folic-acid4.0%83
15
Citalopram-hydrobromide3.9%80

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports trimipramine side effects

62.8% of trimipramine adverse event reports involve female patients and 31.1% involve male patients. The largest age group is adult at 61%. These figures reflect who reports side effects, not underlying risk.

Sex

Female62.8%
Male31.1%
Unknown6.1%

Age group

< 21.3%
2–110.2%
12–171.2%
18–6461.5%
65+35.8%

What is trimipramine used for

Conditions and purposes for which patients were taking trimipramine when the adverse event was reported.

Abnormal BehaviourAdjustment Disorder With Depressed MoodAffective DisorderAggressionAgitated DepressionAntidepressant TherapyAnxietyAnxiety DisorderApathyArthralgiaAttention Deficit/hyperactivity DisorderAffective DisorderAnalgesic TherapyAnorexia And Bulimia SyndromeAntidepressant Therapy

Showing 15 of 99 indications

Trimipramine brand names and reporting trend

Trimipramine is sold under the brand name Trimipramine Maleate.

Brand names

Trimipramine Maleate158

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking trimipramine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.