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Trimetrexate Side Effects

The most commonly reported side effects of trimetrexate include fatigue, vomiting, and feeling abnormal, based on 26 FDA adverse event reports from 2005 to 2023.

Trimetrexate side effects

Percentages show how often each reaction appears relative to total reports for trimetrexate.

1
Fatigue15.4%4
2
Vomiting11.5%3
3
Feeling Abnormal7.7%2
4
Impaired Work Ability7.7%2
5
Headache7.7%2
6
Depression7.7%2
7
Nausea7.7%2
8
Migraine7.7%2
9
Insomnia7.7%2
10
Diarrhoea7.7%2
11
Crying7.7%2
12
Dyspnoea7.7%2
13
Akathisia3.8%1
14
Angina Pectoris3.8%1
15
Ankle Fracture3.8%1

These are voluntary reports and do not establish that trimetrexate caused these reactions.

Report severity

73.1%Serious19 reports
46.2%Hospitalizations12 reports
3.8%Fatal1 reports

Seriousness is determined by the reporter, not by OpenClaim.

Trimetrexate drug interactions

Other drugs that appear in adverse event reports alongside trimetrexate. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Adalimumab15.4%4
2
Certolizumab-pegol7.7%2
3
Topiramate7.7%2
4
Olanzapine3.8%1
5
Gadobenate-dimeglumine3.8%1
6
Ethinyl-estradiol3.8%1
7
Norelgestromin3.8%1
8
Pregabalin3.8%1
9
Pegfilgrastim3.8%1
10
Omalizumab3.8%1
11
Glatiramer-acetate3.8%1
12
Apremilast3.8%1
13
Alprazolam3.8%1
14
Divalproex-sodium3.8%1
15
Levofloxacin3.8%1

Taken alongside

1
Acetaminophen23.1%6
2
Prednisone23.1%6
3
Ergocalciferol23.1%6
4
Levothyroxine-sodium19.2%5
5
Promethazine-hydrochloride19.2%5
6
Omeprazole15.4%4
7
Lisinopril15.4%4
8
Duloxetine-hydrochloride15.4%4
9
Fluticasone11.5%3
10
Hydrochlorothiazide11.5%3
11
Celecoxib11.5%3
12
Ondansetron11.5%3
13
Folic-acid11.5%3
14
Clonazepam7.7%2
15
Lovastatin7.7%2

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports trimetrexate side effects

76.9% of trimetrexate adverse event reports involve female patients and 11.5% involve male patients. The largest age group is adult at 87%. These figures reflect who reports side effects, not underlying risk.

Sex

Female76.9%
Male11.5%
Unknown11.5%

Age group

< 20.0%
2–110.0%
12–170.0%
18–6486.7%
65+13.3%

What is trimetrexate used for

Conditions and purposes for which patients were taking trimetrexate when the adverse event was reported.

ArthritisColorectal CancerMigraineProduct Used For Unknown Indication

Trimetrexate brand names and reporting trend

Trimetrexate is sold under the brand name Neutrexin.

Brand names

Neutrexin23

Quarterly reports (20052023)

20052023

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking trimetrexate with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.