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Trimethobenzamide Side Effects

The most commonly reported side effects of trimethobenzamide include nausea, somnolence, and dizziness, based on 2,592 FDA adverse event reports from 2004 to 2025. 3.8% of reports found the drug to be ineffective.

Trimethobenzamide side effects

Percentages show how often each reaction appears relative to total reports for trimethobenzamide.

1
Nausea13.1%340
2
Somnolence9.3%240
3
Dizziness6.4%166
4
Vomiting6.0%156
5
Yawning4.9%126
6
Fatigue3.9%101
7
Blood Pressure Decreased3.9%101
8
Drug Ineffective3.8%98
9
Asthenia3.5%92
10
Fall3.5%91
11
Diarrhoea2.9%76
12
Nausea2.8%73
13
Dyspnoea2.8%72
14
Product Use In Unapproved Indication2.6%67
15
Blood Pressure Increased2.5%66

These are voluntary reports and do not establish that trimethobenzamide caused these reactions.

Report severity

59.6%Serious1,546 reports
35.7%Hospitalizations926 reports
7.3%Fatal188 reports

Seriousness is determined by the reporter, not by OpenClaim.

Trimethobenzamide drug interactions

Other drugs that appear in adverse event reports alongside trimethobenzamide. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Apomorphine-hydrochloride30.7%795
2
Adalimumab4.8%124
3
Levodopa3.6%94
4
Carbidopa3.2%84
5
Prednisone2.8%72
6
Etanercept2.7%69
7
Tocilizumab2.5%66
8
Golimumab2.1%55
9
Infliximab1.7%45
10
Sodium-oxybate1.7%43
11
Omeprazole1.5%39
12
Acetaminophen1.4%37
13
Esomeprazole1.4%37
14
Certolizumab-pegol1.4%36
15
Abatacept1.2%32

Taken alongside

1
Levodopa20.3%525
2
Carbidopa19.1%494
3
Acetaminophen15.0%389
4
Omeprazole10.4%270
5
Aspirin10.0%259
6
Prednisone9.2%238
7
Levothyroxine-sodium9.1%235
8
Gabapentin7.8%201
9
Albuterol7.5%195
10
Clonazepam7.1%184
11
Ergocalciferol6.9%179
12
Ondansetron6.9%178
13
Hydrocodone6.8%175
14
Furosemide6.3%164
15
Pantoprazole-sodium6.2%161

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports trimethobenzamide side effects

57.3% of trimethobenzamide adverse event reports involve female patients and 36.7% involve male patients. The largest age group is adult at 52%. These figures reflect who reports side effects, not underlying risk.

Sex

Female57.3%
Male36.7%
Unknown6.1%

Age group

< 20.1%
2–110.7%
12–171.2%
18–6452.4%
65+45.6%

What is trimethobenzamide used for

Conditions and purposes for which patients were taking trimethobenzamide when the adverse event was reported.

Abdominal DiscomfortAcute LeukaemiaAcute Lymphocytic LeukaemiaAnkylosing SpondylitisAntiemetic Supportive CareAphthous UlcerArthritisAbdominal DiscomfortAbdominal PainB-cell Type Acute LeukaemiaBehcet^s SyndromeCardiac DisorderColitisCompleted SuicideCrohn^s Disease

Showing 15 of 91 indications

Trimethobenzamide brand names and reporting trend

Trimethobenzamide is sold under the brand name Tigan.

Brand names

Tigan887

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking trimethobenzamide with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.